Summary
Three new analogs of dimethylheptylpyran (DMHP) (SP-141, SP-143, and SP-175) were found to exhibit significant anticonvulsant activity against audiogenic, supramaximal electroshock, and maximal pentylentetrazol induced seizures in mice. In rats, all three compounds were found to be more active than diphenylhydantoin in the supramaximal electroshock test. In particular, a different profile of anticonvulsant activity was demonstrated for SP-175 compared to DMHP or delta-9-THC. It was discovered in 5-day studies that dilantin, phenobarbital, DMHP, and SP-175 do not exhibit tolerance development against audiogenic seizures in mice.
NOTE: We would like to express our appreciation to Dr. Harvey Kupferberg and the Anticonvulsant Advisory Committee of the National Institute of Neurological Diseases and Stroke for their encouragement of this study (supported in part by contract N01-NS-3-2314.)
The authors are indebted to Dr. R. K. Razdan, B. Zitko Terris, and H. G. Pars of the John C. Sheehan Institute for Research and Sharps Associates (SISA), Cambridge, Massachusetts, for the original chemical preparation of the three derivatives of DMHP.
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Plotnikoff, N.P. (1976). New Benzopyrans: Anticonvulsant Activities. In: Cohen, S., Stillman, R.C. (eds) The Therapeutic Potential Of Marihuana. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4286-1_34
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