Abstract
Cannabis has been used as a therapeutic agent since ancient times. Li (1974) and Rosenthal (1971) have described its use by the ancient Chinese and in medieval Arab society. Walton (1938) and more recently Mikuriya (1973) have summarized the medical use of cannabis in Europe during the nineteenth and early twentieth century. In spite of the very promising and rather non-toxic effects of the drug, its use rapidly declined due to the notorious variability of crude cannabis preparations. The advances made since the determination of the structure of cannabidiol in 1963, the isolation in pure form and structure elucidation of delta-1-THC in 1964, and the development of various synthetic routes during the middle sixties (Mechoulam, 1973) have clarified the chemistry and pharmacology of the cannabinoids and have made possible initiation of research into the use of pure natural or synthetic cannabinoids as drugs.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Banerjee, S. P., Snyder, S. H., & Mechoulam, R. Cannabinoids: Influence on neurotransmitter uptake in rat brain synaptosomes. Journal of Pharmacology and Experimental Therapeutics, 1975, 194, 74–81.
Best, M., Pola, R., Galin, M. A., & Blumenthal, M. Tonometric calibration for the rabbit eye. Archives of Opthalmology, 1970, 84, 200–205.
Biel, J. H. & Bopp, B. Antidepressant Drugs. In M. Gordon (Ed.) Psychopharmacological Agents. Vol. III, New York: Academic Press, 1974.
Bogan, W. D., Steele, R. A., & Freedman, D. X. Delta-9-tetrahydrocannabinol effect on audiogenic seizure susceptibility. Psychopharmacologia, 1973, 29, 101–106.
Carlini, E. A., Leite, J. R., Tannhauser, M., & Berardi, A. C. Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents. Journal of Pharmacy and Pharmacology, 1973, 25, 664–665.
Carlini, E. A., Mechoulam, R., & Lander, N. Anticonvulsant activity of four oxygenated cannabidiol derivatives. Research Communications in Chemical Pathology and Pharmacology, 1975 (in press).
Drew, W. G. & Miller, L. L. Cannabis: Neural mechanisms and behavior — a theoretical review. Pharmacology, 1974, 11, 12–32.
Garriott, J. C, Forney, R. B., Hughes, F. W., & Richard, A. B. Pharmacologic properties of some cannabis related compounds. Archives Internationales de Pharmacodynamie et de Therapie, 1968, 171,425–434.
Green, K. & Pederson, J. E. Effect of delta-1-tetrahydrocannabinol on aqueous dynamics and ciliary body permeability in the rabbit. Experimental Eye Research, 1973, 15, 499–507.
Hepler, R. S., Frank, I. M., & Ungerleider, J. T. Pupillary constriction after marijuana smoking. American Journal of Ophthalmology, 1972, 74, 1185–90.
Izquierdo, I., Orsingher, O. A., & Berardi, A. C. Effect of cannabidiol and other Cannabis sdtiva compounds on hippocampal seizure discharges. Psychopharmacologia, 1973, 28, 95–102.
Karler, R., Cely, W., & Turkanis, A. The anticonvulsant activity of cannabidiol and cannabinol. Life Sciences. 1973, 13, 1527–1531.
Lander, N., Ben-Zvi, Z., Mechoulam, R., Martin, B., Nordqvist, M., & Agurell, S. Total syntheses of cannabidiol and delta-1-tetrahydrocannabinol metabolites. Journal of the Chemical Society, Perkin Transactions II, 1975(in press).
Li, H. C. An archeological and historical account of Cannabis in China. Journal of Economic Botany, 1974, 28, 437–448.
Loewe, S. & Goodman, L. S. Anticonvulsant action of marihuana active substances. Federations Proceedings, 1947, 6, 352.
Mechoulam, R. (Ed.) Marijuana chemistry, pharmacology, metabolism and clinical effects. New York: Academic Press, 1973.
Meldrum, B. S. Epilepsy and GABA mediated inhibition. International Review of Neurobiology, 1975, 17, 1–36.
Mikuriya, T. H. (Ed.) Marijuana: Medical Papers 1839–1972. Oakland, Calif.: Medi-Comp Press, 1973.
O’shaughnessy, W. B. On the preparations of the Indian hemp orguniah. Transactions of the Medical and Physical Society of Bombay, 1842, 421–461.
Paton, W. D. M. & Pertwee, R. G. Effects of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism. British Journal of Pharmacology, 1972, 44, 250–261.
Paton, W. D. M. & Pertwee, R. G. The pharmacology of cannabis in animals. In R. Mechoulam (Ed.), Marijuana chemistry, pharmacology, metabolism and clinical effects. New York: Academic Press, 1973.
Reynolds, J. R. Therapeutic uses and toxic effects of Cannabis indica. Lancet I. 1890, 637–638.
Rosenthal, F. The herb hashish versus medieval Muslim society. Leiden: E. J. Brill, 1971.
Schurr, A. & Livne, A. Differential inhibition of mitochondrial monoamine oxidase from brain by hashish components. Biochemical Pharmacology, 1975 (in press).
Schurr, A., Livne, A., & Mechoulam, R., unpublished results.
Shaw, J. On the use of Cannabis indica in tetanus, in hydrophobia and in cholera. Madras Quarterly Medical Journal, 1843, 5, 74–80.
Walton, R. P. Marihuana. America’s new drug problem. Philadelphia: Lippincott, 1938.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Publishing Corporation
About this chapter
Cite this chapter
Mechoulam, R., Lander, N., Dikstein, S., Carlini, E.A., Blumenthal, M. (1976). On the Therapeutic Possibilities of Some Cannabinoids. In: Cohen, S., Stillman, R.C. (eds) The Therapeutic Potential Of Marihuana. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4286-1_3
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4286-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4288-5
Online ISBN: 978-1-4613-4286-1
eBook Packages: Springer Book Archive