Metabolic Protection During Ischemic Cardiac Arrest

  • M. V. Braimbridge
  • D. J. Hearse
  • D. A. Stewart


Open heart surgery requires ideally a still and relaxed heart. Cardiac arrest in diastole can be induced by several procedures (1–10) which may or may not involve coronary perfusion. Clearly coronary perfusion throughout the period of arrest is ideal but the simplicity and practical advantages of ischemic arrest have resulted in its widespread use (7,8). However, the use of ischemic arrest has been criticised (1,11,12,13) because, associated with its prolonged use is the onset of irreversible metabolic and ultrastructural damage. The important question therefore arises:- is there any way in which the ischemic period can be extended or the onset of irreversible damage be reduced or delayed?


Cardiac Arrest Creatine Phosphate Adenosine Triphosphate Aortic Flow Perfusion Fluid 
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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • M. V. Braimbridge
    • 1
  • D. J. Hearse
    • 1
  • D. A. Stewart
    • 1
  1. 1.The Myocardial Metabolism Laboratories, The Rayne InstituteSt. Thomas HospitalLondon

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