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Urinary Purines in a Patient with a Severely Defective T Cell Immunity and a Purine Nucleoside Phosphorylase Deficiency

  • S. K. Wadman
  • P. K. de Bree
  • A. H. van Gennip
  • J. W. Stoop
  • B. J. M. Zegers
  • G. E. J. Staal
  • L. H. Siegenbeek van Heukelom
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Recently a case of purine nucleoside phosphorylase (NP) deficiency was diagnosed in our clinic, which motivated us to start new studies in the immunological and enzymological field. We also decided to study quantitatively the patient’s purine excretions, reflecting the effect of NP deficiency on overall purine metabolism. The results of this work are given in the present paper.

Keywords

Uric Acid Serum Uric Acid Hippuric Acid Purine Metabolism Purine Nucleoside Phosphorylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

  1. 1.
    Stoop, J. W., V. P. Eysvoogel, B. J. M. Zegers, B. Blok-Schut, D. W. van Bekkum and R. E. Ballieux, Clin.Immunol.Immunopath. 1976 (in press)Google Scholar
  2. 2.
    Stoop, J. W., B. J. M. Zegers, G. E. J. Staal, L. H. Siegenbeek van Heukelom, S. K. Wadman and R. E. Ballieux, 1976 (to be published)Google Scholar
  3. 3.
    Edwards, Y. H., D. A. Hopkinson and H. Harris, Ann. hum. Genit., 1971, 34, 395CrossRefGoogle Scholar
  4. 4.
    Kalckar, H. M., J.Biol.Chem., 1947, 167, 429PubMedGoogle Scholar
  5. 5.
    De Bruyn, C. H. M. M., Nijmegen, The Netherlands, personal communicationGoogle Scholar
  6. 6.
    Bonnelycke, B. E., K. Dus and S. L. Miller, Analytical Biochem. 1969, 27, 262CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • S. K. Wadman
    • 1
  • P. K. de Bree
    • 1
  • A. H. van Gennip
    • 1
  • J. W. Stoop
    • 1
  • B. J. M. Zegers
    • 1
  • G. E. J. Staal
    • 1
    • 2
  • L. H. Siegenbeek van Heukelom
    • 1
    • 2
  1. 1.University Children’s Hospital Het Wilhelmina KinderziekenhuisUtrechtThe Netherlands
  2. 2.Medical Enzymology Dept.University HospitalUtrechtThe Netherlands

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