Urinary Purines in a Patient with a Severely Defective T Cell Immunity and a Purine Nucleoside Phosphorylase Deficiency

  • S. K. Wadman
  • P. K. de Bree
  • A. H. van Gennip
  • J. W. Stoop
  • B. J. M. Zegers
  • G. E. J. Staal
  • L. H. Siegenbeek van Heukelom
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Recently a case of purine nucleoside phosphorylase (NP) deficiency was diagnosed in our clinic, which motivated us to start new studies in the immunological and enzymological field. We also decided to study quantitatively the patient’s purine excretions, reflecting the effect of NP deficiency on overall purine metabolism. The results of this work are given in the present paper.

Keywords

Creatinine Adenosine Sarcoma Sine Pyrimidine 

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Literature

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • S. K. Wadman
    • 1
  • P. K. de Bree
    • 1
  • A. H. van Gennip
    • 1
  • J. W. Stoop
    • 1
  • B. J. M. Zegers
    • 1
  • G. E. J. Staal
    • 1
    • 2
  • L. H. Siegenbeek van Heukelom
    • 1
    • 2
  1. 1.University Children’s Hospital Het Wilhelmina KinderziekenhuisUtrechtThe Netherlands
  2. 2.Medical Enzymology Dept.University HospitalUtrechtThe Netherlands

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