Abstract
Stimulation of cardiac ß-adrenergic receptors with isoproterenol results in a considerable enhancement of the biosynthesis of adenine nucleotides (AN) in the rat heart in vivo (17). AN biosynthesis proves also to be increased when the isoproterenol-induced diminution of the concentration of myocardial AN is prevented (19). Thus, release of feedback inhibition of 5-phosphoribosyl-1-pyrophosphate-amidotransferase (EC 2.4.2.14) cannot be exclusively responsible for the acceleration of AN synthesis observed under these conditions (8,16). An alternative mechanism seems to be operative which affects de novo synthesis of AN through the available pool of 5-phosphoribosyl-1-pyrophosphate (PRPP) (9).
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Zimmer, HG., Gerlach, E. (1977). Studies on the Regulation of the Biosynthesis of Myocardial Adenine Nucleotides. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4223-6_5
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DOI: https://doi.org/10.1007/978-1-4613-4223-6_5
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