Skip to main content

Xanthine Oxidase Activity in a Gouty Patient with Partial Deficiency of HGPRT

  • Chapter
Purine Metabolism in Man—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB))

  • 165 Accesses

Abstract

Xanthine oxidase is an enzyme which is directly uricogenetic, as it catalyzes the aerobic dehydrogenation of hypoxanthine to xanthine and of xanthine to uric acid, these being the final steps in purine metabolism in man. In man, the enzyme is present mainly in the liver and in the jejunal mucosa.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Carcassi A., Marcolongo R., Marinello E., Riario-Sforza G., Boggiano C. Liver Xanthine Oxidase in Gouty Patients Arthr. Rheum. 12,17, 1969

    Article  CAS  Google Scholar 

  2. Riario-Sforza G., Carcassi A., Bayeli P.F., Marcolongo R., Marinello E., Montagnani M. Attivita xantina-ossidasica nella mucosa digiunale di soggetti gottosi. B.S.I.B.S. 45,785, 1969

    CAS  Google Scholar 

  3. Ciccoli L., Riario-Sforza G., Marinello E., Marcolongo R., Carcassi A. Relazione tra aumento della xantina ossidasi epatica, iperuricemia e uricuria nei soggetti gottosi. Reumatismo 21, 277, 1969

    PubMed  CAS  Google Scholar 

  4. Mangoni A., Pennetti V., Spadoni M.A. Aumento adattativo di xantina ossidasi in topini alimentati con diete a diverso contenuto proteico. B.S.I.B.S. 31, 1397, 1955

    CAS  Google Scholar 

  5. Delia Corte E., Stirpe F. Regulation of xanthine dehydrogenase in cick liver. Biochem. J. 102, 520, I967

    Google Scholar 

  6. Stirpe F., Della Corte E. Regulation of xanthine dehydrogenase in cick liver. Effect of starvation and of administration of purine and purine nucleosides. Biochem. J. 94, 309, 1965

    PubMed  CAS  Google Scholar 

  7. Bray R.C. Xanthine Oxidase, The Enzymes Vol. 7 Ed. by P. Bayer, Lardy H. Myrback K. New York, Academic Press, pp. 533–556

    Google Scholar 

  8. Marinello E. Carcassi A., Riario-Sforza G., Ciccoli L., Marcolongo R. Effetto di varie sostanze iperuricemizzanti sulla xantina ossidasi epatica di soggetti normali. Reumatismo 21, 310, I969

    Google Scholar 

  9. Riario-Sforza G., Ciccoli L., Marinello E., Marcolongo R., Carcassi A. Comportamento della xantina ossidasi nel fegato di soggetti iperuricemici in seguito a carico di fruttoso. Reumatismo 21, 322, I969

    Google Scholar 

  10. Cartier P., Hamet M. Les activites purine phosphoribosyltransferasiques dans les globules rouges humains. Technique de dosage. Clin. Chim. Acta 20, 205, 1968

    Article  PubMed  CAS  Google Scholar 

  11. Kelley W.N., Rosenbloom F.M. Henderson J.F. Seegmiller J.E. A specific enzyme defect in gout associated with overproduction of uric acid. Proc. Natl. Acad. Sci. U.S. 57, 1735, 1967

    Article  CAS  Google Scholar 

  12. De Bruyn C.H.M.M., Oei T.L. Heterogeneity in X-linked gout. Scand. J. Rheum, suppl. 8, abst. 31–08, 1975

    Google Scholar 

  13. Yü T.F., Balis M.E., Kretinsky T.A., Dancis J. Silvers D.N. Elion G.B., Gutman A.B. Rarity of X-linked partial hypoxanthine-guanine phosphoribosyltransferase deficiency in a large gouty population. Ann. Intern. Med. 76, 255, 1972

    PubMed  Google Scholar 

  14. Sperling O., Boer P., Persky-Broch S., Kanarek E. De Vries A. Altered kinetic property of erythrocyte phosphoribosylpyrophosphate synthetase in excessive purine production. Europ. J. Clin. Biol. Res. 17, 103, 1972

    Google Scholar 

  15. Becker M.A. Meyer L.J. Seegmiller J.E. Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity. Amer. J. Med. 55, 232, 1973

    Article  PubMed  CAS  Google Scholar 

  16. Izar G. Lenzi F. La Gotta. Relazione 55° Congr. Soc. Ital. Med. Int. ed. Pozzi, Roma 1954

    Google Scholar 

  17. Kelley W.N., Greene M.L., Rosenbloom F.M., Henderson J.F., Seegmiller J.E. Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout. Ann. Intern. Med. 70, 155, 1969

    PubMed  CAS  Google Scholar 

  18. Sorenson L.B. Mechanism of excessive purine biosynthesis in hypoxanthineguanine phosphoribosyltransferase deficiency. J. Clin. Invest. 49, 968, 1970

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Plenum Press, New York

About this chapter

Cite this chapter

Carcassi, A. (1977). Xanthine Oxidase Activity in a Gouty Patient with Partial Deficiency of HGPRT. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4223-6_43

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4223-6_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4225-0

  • Online ISBN: 978-1-4613-4223-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics