Abstract
Human erythrocytes are known to form a variety of purine nucleoside triphosphates from the bases and nucleosides, through the action of nucleoside kinases, phosphoribosyltransferases and nucleotide kinases. In addition to ATP and GTP, a very low concentration (6μM) of inosine triphosphate (ITP) was identified in fresh erythrocytes by Vanderheiden (1). More recently, after a 4 hour incubation of stored RBC’s with inosine, Zachara reported that a large amount of ITP was formed (2). A specific ITP pyrophosphohydrolase (3) probably contributes to the low steady state levels of ITP in circulating cells. Inosine has been suggested as a purine source in blood preservation studies (4) and can augment adenine nucleotide pools in studies with ischemic kidneys (5).
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© 1977 Plenum Press, New York
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Nelson, D.J., Buggé, C., Krasny, H.C. (1977). Oxypurine and 6-Thiopurine Nucleoside Triphosphate Formation in Human Erythrocytes. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4223-6_16
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DOI: https://doi.org/10.1007/978-1-4613-4223-6_16
Publisher Name: Springer, Boston, MA
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