Cholesterol Exchange: Evidence for a Role in Arterial Cholesterol Accumulation
Despite the fact that virtually all the cholesterol that accumulates in atherosclerotic arteries has its origin in plasma lipoproteins, the mechanism(s) of net transfer of cholesterol into the arterial wall is unknown. It seems certain that arterial cholesterol accumulation cannot be explained solely on the basis of the simple diffusion of plasma lipoproteins into the artery (1,2). For this reason, other mechanisms such as lipoprotein remnant uptake (3) or cholesterol exchange (4–6) have been proposed. Recent experimental evidence (6) supports the feasibility of the latter mechanism which will be discussed here.
KeywordsArterial Wall Cholesteryl Ester Plasma Lipoprotein Rabbit Aorta Atherosclerotic Artery
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