Use of Esterified Retinol to Trace the Degradation of Chylomicrons in Cholesterol-Fed Rabbits

  • A. Catharine Ross
  • D. B. Zilversmit
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)


In the normal rat (1) and dog (2) chylomicron triglyceride (TG) is rapidly hydrolyzed in peripheral tissues. Partially degraded chylomicrons containing intestinal cholesteryl esters are subsequently taken into liver parenchymal cells (1). Cholesteryl esters may be recirculated in hepatogenous very low density lipoproteins (VLDL). Dietary retinyl esters are co-transported with esterified cholesterol in chylomicrons and are also removed by the liver (3). However, esterified retinol is not recirculated in hepatic VLDL. Esterified retinol may therefore be useful as a specific marker for tracing the degradation of TG-rich VLDL of intestinal origin.


Cholesteryl Ester Control Rabbit Liver Parenchymal Cell Chylomicron Remnant Cholesterol Feeding 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • A. Catharine Ross
    • 1
  • D. B. Zilversmit
    • 1
  1. 1.Division of Nutritional Sciences and Section of Biochemistry, Molecular and Cell BiologyCornell UniversityIthacaUSA

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