Use of Esterified Retinol to Trace the Degradation of Chylomicrons in Cholesterol-Fed Rabbits
In the normal rat (1) and dog (2) chylomicron triglyceride (TG) is rapidly hydrolyzed in peripheral tissues. Partially degraded chylomicrons containing intestinal cholesteryl esters are subsequently taken into liver parenchymal cells (1). Cholesteryl esters may be recirculated in hepatogenous very low density lipoproteins (VLDL). Dietary retinyl esters are co-transported with esterified cholesterol in chylomicrons and are also removed by the liver (3). However, esterified retinol is not recirculated in hepatic VLDL. Esterified retinol may therefore be useful as a specific marker for tracing the degradation of TG-rich VLDL of intestinal origin.
KeywordsCholesterol Hexane Fractionation Triglyceride Retinol
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