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The Heparin Neutralizing Activity Test in the Diagnosis of Acute Myocardial Infarction (MI)

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Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 82))

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Abstract

We have previously shown that the test for heparin neutralizing activity (HNA) shows a significant increase in HNA in patients long after recovery from a myocardial infarct (post-Mi) (O’Brien 1974; O’Brien et al. in the press). There is also increasing evidence that HNA in platelet poor plasma usually reflects platelet factor 4 (PF4) presumably derived from platelets broken down or undergoing release in the circulation. Accordingly it seemed appropriate to study this test in the acute disease (ac-MI). Abnormal tests long after the event may reflect a predisposition to MI: they are unlikely to be the result of the MI. Changes found immediately after the acute event are much more likely to be the result of the episode.

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References

  • O’Brien, J.R. (1974): Anti-thrombin III and heparin clotting times in thrombosis and atherosclerosis. Thrombosis et Diathesis Haemorrhagica, 32:116.

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  • O’Brien, J.R., Etherington, M.D., Jamieson, S. and Klaber, M.R. (1973): Stressed template bleeding time and other platelet function tests in myocardial infarction. Lancet, 1:694.

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  • O’Brien, J.R., Etherington, M.D., Jamieson, S., Lawford, P., Lincoln, S.V. and Alkjaersig, N. (in the press): Blood changes in atherosclerosis and long after myocardial infarction and venous thrombosis. Thrombosis et Diathesis Haemorrhagica.

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Author information

Authors and Affiliations

  1. Portsmouth & S.E. Hampshire District Pathology Service, Central Laboratory, St. Mary’s General Hospital, Portsmouth, England

    J. R. O’Brien, M. D. Etherington, S. Jamieson, P. Lawford & J. Sussex

Authors
  1. J. R. O’Brien
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  2. M. D. Etherington
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  3. S. Jamieson
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  4. P. Lawford
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  5. J. Sussex
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Editor information

Editors and Affiliations

  1. University of Western Ontario, London, Ontario, Canada

    George W. Manning  & M. Daria Haust  & 

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© 1977 Plenum Press, New York

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O’Brien, J.R., Etherington, M.D., Jamieson, S., Lawford, P., Sussex, J. (1977). The Heparin Neutralizing Activity Test in the Diagnosis of Acute Myocardial Infarction (MI). In: Manning, G.W., Haust, M.D. (eds) Atherosclerosis. Advances in Experimental Medicine and Biology, vol 82. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4220-5_19

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  • DOI: https://doi.org/10.1007/978-1-4613-4220-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4222-9

  • Online ISBN: 978-1-4613-4220-5

  • eBook Packages: Springer Book Archive

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