Arterial Cholesterol Esterase

  • David Kritchevsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)

Abstract

Windaus (l) first reported that cholesteryl esters accumulated in atherosclerotic aortas. His findings were confirmed and extended by Böttcher (2) and Smith (3). Newman and Zilversmit (h) demonstrated the steady increase in aortic cholesteryl ester with continuing feeding of cholesterol to rabbits and Kritchevsky and Tepper (5) showed that cholesteryl ester increased in rabbit aortas even when the animals were subjected to a cholesterol-free, atherogenic semipurified regimen. Despite the absence of cholesterol, the diet was hypercholesterolemic and hyperbetalipoproteinemic. The Virchow hypothesis that increased aortic lipid levels were due to filtration of serum gained currency when several groups showed that the lipids of serum and aorta were qualitatively similar (6–8). However, they analyzed adult aortas and adult sera. Analysis of infant’s aortas shows almost complete absence of cholesteryl ester (9). The work of Dayton and Hashimoto (10,11) and of Smith (3) now leaves little doubt than an appreciable amount of aortic cholesteryl ester arises from synthesis in situ.

Keywords

Cholesterol Hydrolysis Corn Ethyl Oleate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. Windaus, Z. Physiol. Chem. 67:174, 1910.CrossRefGoogle Scholar
  2. 2.
    C.F.J. Bottcher in “Drugs Affecting Lipid Metabolism”. Eds. S. Garattini and R. Paoletti; Elsevier, Amsterdam, 1961, p. 54.Google Scholar
  3. 3.
    E.B. Smith. J. Atheroscler. Res. 5:224, 1965PubMedCrossRefGoogle Scholar
  4. 4.
    H.A.I. Newman and D.B. Zilversmit. J. Atheroscler. Res. 4: 261, 1964.PubMedCrossRefGoogle Scholar
  5. 5.
    D. Kritchevsky and S.A. Tepper. J. Atheroscler. Res. 8:357, 1968.PubMedCrossRefGoogle Scholar
  6. 6.
    S. Weinhouse and E.F. Hirsch. Arch. Pathol. 29:31, 1940.Google Scholar
  7. 7.
    I.H. Page. Ann. Int. Med. 14:1741, 1941.Google Scholar
  8. 8.
    J.F. Mead and M.L. Gouze. Proc. Soc. Exp. Biol. Med. 106: 4, 1961.PubMedGoogle Scholar
  9. 9.
    N. Tuna and H.K. Mangold, in “Evolution of the Atherosclerotic Plaque”. Ed. R.J. Jones; Univ. of Chicago Press, Chicago. 1963, P. 85.Google Scholar
  10. 10.
    S. Dayton and S. Hashimoto. Exp. Molec. Pathol. 13:253, 1970.CrossRefGoogle Scholar
  11. 11.
    S. Dayton and S. Hashimoto. Atherosclerosis 12:371, 1970.PubMedCrossRefGoogle Scholar
  12. 12.
    H.V. Kothari, B.F. Miller and D. Kritchevsky. Biochim. Biophys. Acta 296:446, 1973.PubMedGoogle Scholar
  13. 13.
    H.V. Kothari and D. Kritchevsky. Lipids 10:322, 1975.PubMedCrossRefGoogle Scholar
  14. 14.
    D. Kritchevsky and H.V. Kothari. Steroids and Lipids Res. 5:23, 1974.Google Scholar
  15. 15.
    D. Kritchevsky and H.V. Kothari. Biochim. Biophys. Acta 326: 489, 1973.PubMedGoogle Scholar
  16. 16.
    D. Kritchevsky, S.A. Tepper, J.C. Genzano and H.V. Kothari. Atherosclerosis 19:459, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    S. Pearson, S. Stern and T.H. McGavack. Analyt. Chem. 25: 813, 1953.CrossRefGoogle Scholar
  18. 18.
    R.W. St. Clair, H.B. Lofland and T.B. Clarkson. Circulation Res. 27:213, 1970.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • David Kritchevsky
    • 1
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

Personalised recommendations