Arterial Cholesterol Esterase
Windaus (l) first reported that cholesteryl esters accumulated in atherosclerotic aortas. His findings were confirmed and extended by Böttcher (2) and Smith (3). Newman and Zilversmit (h) demonstrated the steady increase in aortic cholesteryl ester with continuing feeding of cholesterol to rabbits and Kritchevsky and Tepper (5) showed that cholesteryl ester increased in rabbit aortas even when the animals were subjected to a cholesterol-free, atherogenic semipurified regimen. Despite the absence of cholesterol, the diet was hypercholesterolemic and hyperbetalipoproteinemic. The Virchow hypothesis that increased aortic lipid levels were due to filtration of serum gained currency when several groups showed that the lipids of serum and aorta were qualitatively similar (6–8). However, they analyzed adult aortas and adult sera. Analysis of infant’s aortas shows almost complete absence of cholesteryl ester (9). The work of Dayton and Hashimoto (10,11) and of Smith (3) now leaves little doubt than an appreciable amount of aortic cholesteryl ester arises from synthesis in situ.
KeywordsNicotinic Acid Cholesteryl Ester Atherogenic Diet Rabbit Aorta Serum Total Cholesterol Level
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