Pathophysiology of the Intercellular Matrix as a Whole

  • L. Robert
  • A. M. Robert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)


Arterial wall contains cellular elements and intercellular matrix. The relative importance of the matrix elements varies from the basement membrane in capillaries to a relatively abundant and complex “matrix” in larger arteries of the “elastic” type. This contains all four major classes of the intercellular matrix macromolecules (IMM): Collagen, Elastin, Proteoglycans and Structural Glycoproteins. The relative proportion of these macromolecules varies also from artery to artery and even in the same artery according to its anatomical location. The differentiation of the cellular elements of the arterial wall during morphogenesis appears to imply the definition of a “program” of biosynthesis of these IMM-s, this program being different according to the anatomical location and the functional role of the artery. This “program” of IMM-biosynthesis changes also with age and appears to be modified in pathological conditions. The study of arterial wall connective tissues “as a whole” is conditioned by the understanding of the mechanisms underlying the “program” of biosynthesis of the IMM-s as well as the mechanisms of their degradation.


Arterial Wall Cellular Element Adult Rabbit Rabbit Aorta Human Aorta 
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  1. 1-.
    J. Ouzilou, A.M. Robert, L. Robert, H. Bouissou and M.T. Pieraggi., Paroi Artérielle, 1, 105–116 (1973)Google Scholar
  2. 2-.
    M. Bihari-Varga and S. Gerö., in “Protides of the Biological Fluids”, ed. H. Peeters (Pergamon Press) 22, 319–322 (1975)Google Scholar
  3. 3-.
    M. Bihari-Varga, J. Feher, M. Varsanyi, S. Gerö, Acta Med. Acad. Sci. Hung. 29, 217–229 (1972)Google Scholar
  4. 4-.
    J. Fehér, M. Bihari-Varga, M. Varsanyi and S. Gerö, Brit. J. Exp. Path. 53, 509–517 (1972)PubMedGoogle Scholar
  5. 5-.
    M. Bihari-Varga, C. Sepulchre and E. Moczar, J. Thermal Analysis 7, 675–683 (1975)CrossRefGoogle Scholar
  6. 6-.
    L. Robert, S. Junqua, A.M. Robert, M. Moczar and B. Robert, in “Biology of Fibroblast” ed E. Kulonen and J. Pikkarainen (Acad. Press, London/New-York) pp 637–652 (1973)Google Scholar
  7. 7-.
    H. Jellinek, “Arterial Lesions and Arteriosclerosis” (Plenum Press, London/New York) 1974CrossRefGoogle Scholar
  8. 8-.
    L. Robert, A. Kadar and B. Robert., in “Arterial Mesenchyme and Arteriosclerosis” eds W.D. Wagner and T.B. Clarkson (Plenum Press, New-York/London) 43, 85–124 (1974)CrossRefGoogle Scholar
  9. 9-.
    Y. Moschetto, M. De Backer, O. Pizieux, H. Bouissou, M.T. Pieraggi and M. Julian, Paroi Arterielle 2, 161–178 (1974)Google Scholar
  10. 10-.
    J. Ouzilou, Y. Courtois, M. Moczar and L. Robert, C.R. Acad. Sc. Paris 280, 209–212 (1975)Google Scholar
  11. 11-.
    M. Moczar, J. Ouzilou, Y. Courtois and L. Robert, in preparationGoogle Scholar
  12. 12-.
    J. Renais, P. Hadjiisky and L. Scebat, in “Arterial Mesenchyme and Arteriosclerosis” ed. W.D. Wagner and T.B. Clarkson (Plenum Press, New-York/London) 43, 335–354 (1974)CrossRefGoogle Scholar
  13. 13-.
    A.M. Robert, Y. Grosgogeat, V. Reverdy, B. Robert and L. Robert, Atherosclerosis 13, 427–449 (1971)PubMedCrossRefGoogle Scholar
  14. 14-.
    S. Gerö, J. Székely, E. Szondy, A. Zobbagy, A. Orosz and E. Seregélyi, Experientia 29, 1024 (1973)PubMedCrossRefGoogle Scholar
  15. 15-.
    K. Fisher-Dzoga, R. Chen and R.W. Wissler, in “Arterial Mesenchyme and Arteriosclerosis” ed. W.D. Wagner and T.B. Clarkson (Plenum Press, London/New-York) 43, 299–314 (1974)CrossRefGoogle Scholar
  16. 16-.
    B. Jacotot, J.L. Beaumont, G. Monnier, M. Szigeti, B. Robert and L. Robert, Nutr. Metabol. 15, 46–58 (1973)CrossRefGoogle Scholar
  17. 17-.
    M. Claire, B. Jacotot, L. Robert and J.L. Beaumont, in “Protides of the Biological Fluids” ed. H. Peeters (Pergamon Press, Oxford/New York) 22, 167–170 (1975)Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • L. Robert
    • 1
  • A. M. Robert
    • 1
  1. 1.Laboratoire de Biochimie du Tissu ConjonctifFac. Méd., Univ. Paris-Val de MarneCréteilFrance

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