The Effects of Nutrition on Lipid Metabolism

  • William E. Connor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)

Abstract

Nutritional factors have important effects upon lipid metabolism in man and indeed play the dominant role in the pathogenesis of the hyperlipidemia and atherosclerosis so commonly found in populations of the Western World. Many past investigations have documented that certain dietary substances have decisive effects upon the serum lipid concentrations and the sterol balance of the body. These dietary factors are sterols, fats and total calories. This review will focus upon a discussion of their roles. Other substances whose effects are to date less well defined but which may have some influence especially in certain individuals, include carbohydrates, fiber and alcohol. Proteins, minerals and vitamins have little or no effect upon lipid metabolism in amounts and kinds typically consumed by the American population.

Keywords

Cholesterol Obesity Ethyl Carbohydrate Triglyceride 

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References

  1. 1.
    Connor, W.E. and Connor, S.L. The Key Role of Nutritional Factors in the Prevention of Coronary Heart Disease. Prev. Med. 1:49, 1972.PubMedCrossRefGoogle Scholar
  2. 2.
    Keys, A., Anderson, J.T., Mickelson, O., Adelson, S.F. and Fidanza, F. Diet and Serum Cholesterol in Man: Lack of Effect of Dietary Cholesterol. J. Nutr. 59:39, 1956.PubMedGoogle Scholar
  3. 3.
    Connor, W.E., Hodges, R.E. and Bleiler, R.E. The Effect of Dietary Cholesterol Upon the Serum Lipids in Man. J. Lab. Clin. Med. 57:331, 1961.PubMedGoogle Scholar
  4. 4.
    Connor, W.E., Hodges, R.E. and Bleiler, R.E. The Serum Lipids in Men Receiving High Cholesterol and Cholesterol-Free Diets. J. Clin. Invest. 40:894, 1961.PubMedCrossRefGoogle Scholar
  5. 5.
    Connor, W.E., Stone, D.B. and Hodges, R.E. The Interrelated Effects of Dietary Cholesterol and Fat Upon the Human Serum Lipid Levels. J. Clin. Invest. 43:1691, 1964.PubMedCrossRefGoogle Scholar
  6. 6.
    Beveridge, J.M.R., Connell, W.F., Mayer, G.A. and Haust, H.L. The Response of Man to Dietary Cholesterol. J. Nutr. 71:61, 1960.PubMedGoogle Scholar
  7. 7.
    Steiner, A., Howard, E.J. and Akgun, S. Importance of Dietary Cholesterol in Man. J. Am. Med. Assoc. 181:186, 1962.CrossRefGoogle Scholar
  8. 8.
    Connor, W.E., and Lin, D.S. The Intestinal Absorption of Dietary Cholesterol by Hypercholesterolemic (Type II) and Normo-cholesterolemic Humans. J. Clin. Invest. 53:1062, 1974.PubMedCrossRefGoogle Scholar
  9. 9.
    Grundy, S.M., Ahrens, E.H., Jr. and Davignon, J. The Interaction of Cholesterol Absorption and Cholesterol Synthesis in Man. J. Lip. Res. 10:304, 1969.Google Scholar
  10. 10.
    Bhattacharyya, A.K., Connor, W.E., Mausolf, F.A. and Flatt, A.E. Turnover Xanthoma Cholesterol in Hyperlipoproteinemic Patients. J. Lab. and Clin. Med. (in press).Google Scholar
  11. 11.
    Connor, W.E. and Jagannathan, S.N. Increased Beta Lipoprotein Cholesterol from the Feeding of Dietary Cholesterol to Normal and Hyperlipoproteinemic Subjects. Submitted for publication.Google Scholar
  12. 12.
    Bhattacharyya, A.K. and Connor, W.E. Betasitosterolemia and Xanthomatosis: A Newly Described Lipid Storage Disease in Two Sisters. J. Clin. Invest. 53:1033, 1974.PubMedCrossRefGoogle Scholar
  13. 13.
    Mellies, M., Glueck, C.J., Sweeney, C., Fallat, R., Tsang, R. and Ishikawa, T.T. Plasma and Dietary Phytosterols in Children. Pediatrics. In press, 1975.Google Scholar
  14. 14.
    Connor, W.E., Witiak, D.T., Stone, D.B. and Armstrong, M.L. Cholesterol Balance and Fecal Neutral Steroid and Bile Acid Excretion in Normal Men Fed Dietary Fats of Different Fatty Acid Composition. J. Clin. Invest. 48:1363, 1969.PubMedCrossRefGoogle Scholar
  15. 15.
    Moore, R.B., Anderson, J.T., Taylor, H.L., Keep, A. and Frantz, I.D., Jr. Effect of Dietary Fat on the Fecal Excretion of Cholesterol and its Degradation Products in Man. J. Clin. Invest. 47:1517, 1968.PubMedCrossRefGoogle Scholar
  16. 16.
    Olefsky, J., Reaven, G.M. and Farquahr, J.W. Effects of Weight Reduction on Obesity. J. Clin. Invest. 53:64, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    Galbraith, W.B., Connor, W.E. and Stone, D.B. Weight Loss and Serum Lipid Changes in Obese Subjects Given Low Calorie Diets of Varied Cholesterol Content. Ann. Int. Med. 64:268, 1966.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • William E. Connor
    • 1
  1. 1.The Department of MedicineUniversity of Oregon School of MedicinePortlandUSA

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