Mural Thrombosis and Plaque Growth
The suggestion that thrombosis may play a part in the growth of atherosclerotic plaques is by no means new since it was first put forward by Rokitansky some 130 years ago. Duguid in 1946 revived interest in what has been called the “thrombogenic hypothesis” a poor term since it appears to carry for some the connotation that mural thrombosis is the initiating factor in atherogenesis. Assessment of the possible role of mural thrombosis in plaque growth can be carried out, basically in two ways. The first of these depends on identidfication of thrombotic residua in atherosclerotic plaques, the determination of the frequency with which this occurs and the relationship, if any, to the presence of clinically significant occlusive arterial disease. The second approach to the problem lies in a study of the natural history of experimentally induced thrombosis in a variety of animal species.
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