Abstract
The kidney is uniquely involved in the maintenance of body calcium, magnesium, phosphorus, and acid-base balance, both as an endocrine secretory and a target organ. In this light, the kidney reabsorbs calcium and phosphorus more avidly under the stimulus of 25-hydroxycholecalciferol (1–4) while it effects conversion of this compound to the metabolite 1,25-dihydroxycholecalciferol, which is more active on gut (5,6). Controversy exists, however, as to the necessity for parathyroid hormone (PTH) to facilitate the renal actions of 25-hydroxycholecalciferol (1–4,7,8). The present studies were undertaken therefore to examine the affect of 25-hydroxycholecalciferol, henceforth referred to as 25-HCC, on the renal handling of calcium, magnesium and phosphate in the intact and acutely thyroparathyroidectomized dog. Since the absorption of phosphate in the latter preparation is virtually complete, bicarbonate infusion was used to increase its excretion.
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© 1977 Springer Science+Business Media New York
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Peraino, R.A., Ghaffary, E., Rouse, D., Suki, W.N. (1977). Renal Actions of 25-Hydroxyvitamin D3 . In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_9
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DOI: https://doi.org/10.1007/978-1-4613-4217-5_9
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