Renal Adenylate Cyclase, Calcitonin Receptors and Phosphate Excretion in Rats Immunized Against Tubular Basement Membranes

  • N. Loreau
  • J. P. Cosyns
  • C. Lepreux
  • R. Ardaillou
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Specific receptors for calcitonin (CT) (1,2) and CT-sensitive adenylate cyclase (3,4) have been clearly demonstrated in cellular membranes purified from rat kidney cortex. We tried to obtain an experimental model in the rat devoid of CT receptors in order to correlate the absence of binding and adenylate cyclase stimulation in vitro with physiological disorders in vivo. This model was obtained after active immunization of Brown Norway rats with heterologous tubular basement membrane (TBM). The immunological and pathological study of this experimental nephritis has been already performed by Lehman, Wilson and Dixon (5).

Keywords

Phosphorus Creatinine Fluoride Calcitonin Nephritis 

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References

  1. 1.
    Marx, S.J., Woodard, C.J., Aurbach, G.D., Glossmann, H., and Keutmann, H.T. Renal receptors for calcitonin: binding and degradation of hormone. J. Biol. Chem. 248:4797, 1973.PubMedGoogle Scholar
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    Marx, S.J., Woodard, C.J., Aurbach, G.D. Calcitonin receptors of kidney and bone. Science 178:199, 1972.Google Scholar
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    Loreau, N., Lepreux, C., Ardaillou, R. Calcitonin-sensitive adenylate cyclase in rat tubular membranes. Biochem. J. 150: 305, 1975.PubMedGoogle Scholar
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    Lehman, D.J., Wilson, C.B., Dixon, F.J. Interstitial nephritis in rats immunized with heterologous tubular basement membrane. Kidney Int. 5:187, 1974.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • N. Loreau
    • 1
  • J. P. Cosyns
    • 1
  • C. Lepreux
    • 1
  • R. Ardaillou
    • 1
  1. 1.I. N. S. E. R. M. 64Tenon hospitalParisFrance

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