Renal Adenylate Cyclase, Calcitonin Receptors and Phosphate Excretion in Rats Immunized Against Tubular Basement Membranes
Specific receptors for calcitonin (CT) (1,2) and CT-sensitive adenylate cyclase (3,4) have been clearly demonstrated in cellular membranes purified from rat kidney cortex. We tried to obtain an experimental model in the rat devoid of CT receptors in order to correlate the absence of binding and adenylate cyclase stimulation in vitro with physiological disorders in vivo. This model was obtained after active immunization of Brown Norway rats with heterologous tubular basement membrane (TBM). The immunological and pathological study of this experimental nephritis has been already performed by Lehman, Wilson and Dixon (5).
KeywordsAdenylate Cyclase Interstitial Nephritis Adenylate Cyclase Activity Salmon Calcitonin Pertussis Vaccine
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