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Transepithelial Transport of Phosphate Anion in Kidney. Potential Mechanisms for Hypophosphatemia

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Book cover Phosphate Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 81))

Abstract

The kidney is an important determinant of endogenous Pi pools in the mammal. Pi is filtered with plasma water and the major fraction of the filtered load is then reabsorbed by the tubule; a variable remainder is excreted (1–3). Many endogenous factors including PTH, Ca2+ and pH influence the process of net reabsorption, or reclamation, and it is now apparent that transepithelial transport of Pi in mammalian kidney is more complex than was anticipated from the classic observations of Pi reclamation (4, 5). Accordingly, we will consider the phenomenon of transepithelial transport which underlies net reabsorption, and the evidence for heterogeneity between nephrons, and within nephrons, in the response to regulatory events which influence Pi transport.

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Authors and Affiliations

  1. Research Inst., Medical Research Council Genetics Group, McGill University-Montreal Children’s Hosp, 2300 Tupper St., Montreal, Quebec, H3H 1P3, Canada

    C. R. Scriver, T. E. Stacey, H. S. Tenenhouse & W. A. MacDonald

Authors
  1. C. R. Scriver
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  2. T. E. Stacey
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  3. H. S. Tenenhouse
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  4. W. A. MacDonald
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz

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© 1977 Springer Science+Business Media New York

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Scriver, C.R., Stacey, T.E., Tenenhouse, H.S., MacDonald, W.A. (1977). Transepithelial Transport of Phosphate Anion in Kidney. Potential Mechanisms for Hypophosphatemia. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_5

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  • DOI: https://doi.org/10.1007/978-1-4613-4217-5_5

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