The Action of 1αhydroxy Vitamin D3 and Phosphate Supplements in Hypophosphataemic Osteomalacia
Vitamin D resistant hypophosphataemic osteomalacia (VDRHPO) occurs as an inherited disorder or more unusually in association with certain connective tissue tumours1. The primary defect is considered to be a failure of phosphate transport with decreased tubular phosphate reabsorption and hypophosphataemia resulting in osteomalacia and myopathy2.
KeywordsBone Turnover Urine Calcium Urine Hydroxyproline Plasma Phosphate Phosphate Supplement
Unable to display preview. Download preview PDF.
- 1.WILLIAMS, T.F. and WINTERS, R.W. Familial (Hereditary) Vitamin D — Resistant Rickets with hypophosphatemia. In The Metabolic Basis of Inherited Disease. Ed. Stanbury, J.B. Wyngaarden, J.B. and Fredrickson, D.S., McCraw-Hill, New York, 1972.Google Scholar
- 3.HAUSSLER, M.R., BAYLINK, D.J., HUGHES, M.R., BRUMBAUGH, P.F., WERGEDAL, J.F., SHEN, F.H., NIELSON, R.L., COUNTS, S.J., BURSAC, K.M. and MCCAIN, T.A. The assay of la, 25 Dihydroxy Vitamin D~. Physiologic and pathologic modulation of circulating hormone levels. Clinical Endocrinology 5, 151s–165s, 1976.CrossRefGoogle Scholar
- 4.Calcium, Phosphate and Magnesium Metabolism: Clinical Physiology and Diagnostic Procedures. Ed. B.E.C. Nordin. Churchill Livingstone, Edinburgh, 1976.Google Scholar
- 5.PEACOCK, M., NORDIN, B.E.C., GALLAGHER, J.C and VARNAVIDES, C. Action of 1α-Hydroxy Vitamin D3 in Man. pp 604–611. In: Vitamin D and Problems Related to Uremic Bone Disease. Ed. Norman, A.W., Schaefer, K. Grigoleit, H.G., Herrath, D.V., Ritz, E. de Gruyter, Berlin, 1975.Google Scholar