Abstract
Extracellular phosphate concentration can only remain constant when the input and the output from the extracellular space are equal. The main input is dietary, from the phosphate bound in food; the only output is through the kidney. This is the case not only in man but probably throughout the whole vertebrate subphylum1. In man the rate at which phosphate is filtered through the glomerular membrane at a normal plasma phosphate concentration is about 4500 mg/day. This is much more than the average 750 mg/day absorbed from the gut. Excessive loss of phosphate from the extracellular fluid is prevented by tubular reabsorption. These two renal operations, glomerular filtration and tubular reabsorption, largely determine the level and constancy of the plasma phosphate2.
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Bijvoet, O.L.M., Reitsma, P.H. (1977). Phylogeny of Renal Phosphate Transport in the Vertebrates. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_4
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DOI: https://doi.org/10.1007/978-1-4613-4217-5_4
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