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Occurrence of Hyperparathyroidism in Children with X-Linked Hypophosphatemia under Treatment with Vitamin D and Phosphate

  • P. H. Krohn
  • G. Offermann
  • M. Brandis
  • J. Brodehl
  • K. Hanke
  • G. Offner
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

X-linked familial hypophosphatemia (XLH) is a hereditary disorder of phosphate metabolism. The marked reduction of renal tubular phosphate reabsorption is followed by chronic hypophosphatemia with rickets and growth retardation. The rickets are resistant to a normal dosage of vitamin D, but they can be healed or prevented by pharmacological doses of vitamin D. An additional oral phosphate substitution was shown by West (1) and Glorieux (2) to induce growth acceleration.

Keywords

Tubular Reabsorption Serum Parathyroid Hormone Phosphate Reabsorption Phosphate Loading Oral Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • P. H. Krohn
    • 1
  • G. Offermann
    • 1
  • M. Brandis
    • 1
  • J. Brodehl
    • 1
  • K. Hanke
    • 1
  • G. Offner
    • 1
  1. 1.Kinderklinik, Med. Hochschule HannoverMedizinische KlinikFU BerlinGermany

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