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Phosphate Metabolism pp 333–344Cite as

Sodium-Dependent Transport of Orthophosphate in Nerve Fibres

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 81))

Abstract

The mechanism by which orthophosphate is concentrated in cells against an electrochemical concentration gradient has so far not been studied in detail. At first sight, such studies appear difficult and laborious, since transmembrane fluxes of phosphate are small (1) and since phosphate is involved in numerous metabolic reactions. An indication that a Na-dependent mechanism might be involved comes from experiments of Chambers (2) who observed that the uptake of labelled phosphate in sea urchin eggs is decreased when the Na of the sea-water is replaced by other cations. Later, Harrison and Harrison (3) observed a similar effect of Na on phosphate transport in rat intestine. At that time, however, little was known on Na-dependent transport processes so that these authors did not study the effect of Na in more detail.

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References

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Authors and Affiliations

  1. Département de Pharmacologie, Ecole de Médecine, CH - 1211, Genève 4, Germany

    R. W. Straub, J. Ferrero, P. Jirounek, M. Rouiller & A. Salamin

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  1. R. W. Straub
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  2. J. Ferrero
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  3. P. Jirounek
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  4. M. Rouiller
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  5. A. Salamin
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz

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© 1977 Springer Science+Business Media New York

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Straub, R.W., Ferrero, J., Jirounek, P., Rouiller, M., Salamin, A. (1977). Sodium-Dependent Transport of Orthophosphate in Nerve Fibres. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_33

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  • DOI: https://doi.org/10.1007/978-1-4613-4217-5_33

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-4219-9

  • Online ISBN: 978-1-4613-4217-5

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