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Renal Handling of Phosphate: Update

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Phosphate Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 81))

Abstract

Phosphate is predominantely reabsorbed in the proximal tubule (1, 2) and this reabsorption is inhibited by parathyroid hormone (PTH) (3, 4). However, in both normal and TPTX animals, phosphate delivery beyond the point of micropuncture in the late proximal tubule exceeds that excreted in the urine (3–11). Furthermore, most investigators report an increase in delivery of phosphate from the proximal tubule but only a moderate phosphaturia after saline expansion in TPTX animals (3, 4, 6, 11). This blunting of the saline induced phosphaturia in TPTX animals has been interpreted as evidence for distal phosphate reabsorption. Similarly, the phosphaturia induced by acetazolamide is also blunted in TPTX animals. From these studies it was concluded that PTH, although it has effects similar to acetazolamide on the proximal tubule, also has a more distal site of action (10, 12). Since these latter conclusions were derived from micropuncture studies where only proximal tubules were punctured, the site of altered phosphate reabsorption could be in any segment beyond the point of micropuncture.

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References

  1. Strickler JC, Thompson DD, Klose RM, and Giebisch G: Micro-puncture study of inorganic phosphate excretion in the rat. J Clin Invest 43:1596–1607, 1964

    Article  CAS  Google Scholar 

  2. Staum BB, Hamburger RJ, and Goldberg M: Tracer microinjection study of renal tubular phosphate reabsorption in the rat. J Clin Invest 51:2271–2276, 1972

    Article  CAS  Google Scholar 

  3. Wen SF: Micropuncture studies of phosphate transport in the proximal tubule of the dog. J Clin Invest 53:143–153, 1974

    Article  CAS  Google Scholar 

  4. Knox FG, and Lechene CP: Distal site of action of parathyroid hormone on phosphate reabsorption. Am J Physiol 229:1556–1560, 1975

    Article  CAS  Google Scholar 

  5. Amiel C, Kuntziger HE, and Richet G: Micropuncture study of handling of phosphate by proximal and distal nephron in normal and parathyroidectomized rat. Evidence for distal reabsorption. Pflügers Arch 317:93–109, 1970

    Article  CAS  Google Scholar 

  6. Maesaka JK, Levitt MF, and Abramson RG: Effect of saline infusion on phosphate transport in intact and thyroparathyroidecto-mized rats. Am J Physiol 225:1421–1429, 1973

    Article  CAS  Google Scholar 

  7. Kuntziger HE, Amiel C, Roinel N, and Morel F: Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium. Am J Physiol 227:905–911, 1974

    Article  CAS  Google Scholar 

  8. Chiu PJS, Agus ZS, and Goldberg M: Effect of thyroparathyroidectomy (TPTX) on renal phosphate transport in the rat. Clin Res 32:520, 1974

    Google Scholar 

  9. Greger RF, Lang FC, Marchand GR, and Knox FG: Re-examination of renal phosphate handling in acutely thyroparathyroidectomized and normal rats with an ultramicromodification of a chemical phosphate method. Clin Res. 24:468, 1976.

    Google Scholar 

  10. Beck LH, and Goldberg M: Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium and phosphate. Am J Physiol 224:1136–1142, 1973

    Article  CAS  Google Scholar 

  11. Beck LH, and Goldberg M: Mechanism of the blunted phosphaturia in saline-loaded thyroparathyroidectomized dogs. Kidney Int 6:18–23, 1974

    Article  CAS  Google Scholar 

  12. Knox FG, Haas JA, and Lechene CP: Effect of parathyroid hormone on phosphate reabsorption in the presence of acetazolamide. Kidney Int. 10:216–220, 1976.

    Article  CAS  Google Scholar 

  13. Brunette MG, Taleb L, and Carriere S: Effect of parathyroid hormone on phosphate reabsorption along the nephron of the rat. Am J Physiol 225:1076–1081, 1973

    Article  CAS  Google Scholar 

  14. Knox FG, Schneider EG, Willis LR, Strandhoy JW, and Ott CE: Site and control of phosphate reabsorption by the kidney. Kidney Int 3:347–353, 1973

    Article  CAS  Google Scholar 

  15. Greger RF, Lang FC, Marchand GR, and Knox FG: Nephron sites of phosphate reabsorption in thyroparathyroidectomized rat. Fed Proc 35:466, 1976

    Google Scholar 

  16. Pitts RF: The excretion of urine in the dog. Am J Physiol 106:1–8, 1933

    Article  CAS  Google Scholar 

  17. Webster GD, Mann JB, and Hills AG: The effect of phosphate infusions upon renal phosphate clearance in man: evidence for tubular phosphate secretion. Metabolism 16:797–814, 1967

    Article  CAS  Google Scholar 

  18. Ginsburg JM: Effect of glucose and free fatty acid on phosphate transport in dog kidney. Am J Physiol 222:1153–1160, 1972

    Article  CAS  Google Scholar 

  19. Handler JS: A study on renal phosphate excretion in the dog. Am J Physiol 202:787, 1962

    Article  CAS  Google Scholar 

  20. Murayama Y, Morel F, and LeGrimellac C: Phosphate, calcium and magnesium transfers in proximal tubules and loops of Henle, as measured by single nephron microperfusion experiments in the rat. Pflügers Arch 338:1–16, 1972

    Article  Google Scholar 

  21. Boudry J-F, Troehler U, Touabi M, Fleisch H, and Bonjour J-F: Secretion of inorganic phosphate in the rat nephron. Clin Sci Mol Med 48:475–489, 1975

    CAS  Google Scholar 

  22. Lang FC, Greger RF, Knox FG, and Lechene CP: Microperfusion studies of phosphate (PO4) and a calcium (Ca) influx in proximal tubules of rats and dogs. Fed Proc (in press), 1976

    Google Scholar 

  23. Pitts RF, and Alexander RS: The renal reabsorptive mechanism for inorganic phosphate in normal and acidotic dogs. Am J Physiol 142:648–662, 1944

    Article  CAS  Google Scholar 

  24. Reiss E, Canterbury JM, Bercovita MA, and Kaplan EL: The role of phosphate in the secretion of parathyroid hormone in man. J Clin Invest 49:2146–2149, 1970

    Article  CAS  Google Scholar 

  25. Frick A: Reabsorption of inorganic phosphate in the rat kidney. I. Saturation of transport mechanism. II. Suppression of fractional phosphate reabsorption due to expansion of extracellular fluid volume. Pflügers Arch 304:351–364, 1968

    Article  CAS  Google Scholar 

  26. Hogben CA, and Bollman JL: Renal reabsorption of phosphate: normal and thyroparathyroidectomized dog. Am J Physiol 164:670–681, 1951

    Article  CAS  Google Scholar 

  27. Foulks JG: Homeostatic adjustment in the renal tubular transport of inorganic phosphate in the dog. Can J Biochem Physiol 33:638–650, 1955

    Article  CAS  Google Scholar 

  28. Eggleton MG, and Habib YA: Urinary excretion of phosphate in man and the cat. J Physiol (Lond) 111:423–436, 1950

    Article  CAS  Google Scholar 

  29. Engle JE, and Steele TH: Renal phosphate reabsorption in the rat: effect of inhibitors. Kidney Int 8:98–104, 1975

    Article  CAS  Google Scholar 

  30. Bonjour JP, Muhlbauer R, Troehler U, and Fleisch H: Regulation and site of the tubular transport of inorganic phosphate (Pi) in the rat kidney. Intern Symp Urolith Res March 29-April 1, 1976 Davos, Switzerland

    Google Scholar 

  31. Hellman D, Baird HR, and Bartter FC: Relationship of maximal tubular phosphate reabsorption to filtration rate in the dog. Am J Physiol 207:89–96, 1964

    Article  CAS  Google Scholar 

  32. Cuche JL, Ott CE, Marchand GR, Diaz-Buxo JA, and Knox FG: Intrarenal role of calcium in phosphate handling. Am J Physiol 230:790–796, 1976

    Article  CAS  Google Scholar 

  33. Massry SG, Coburn JW, and Kleeman CR: The influence of extracellular volume expansion on renal phosphate reabsorption in the dog. J Clin Invest 48:1237–1245, 1969

    Article  CAS  Google Scholar 

  34. Lang FC, Greger RF, Marchand GR, and Knox FG: Saturation kinetics of phosphate reabsorption: Microperfusion studies on the renal proximal tubule of the thyroparathyroidectomized rat. Clin Res 24:405, 1976

    Google Scholar 

  35. Potts JT Jr, and Deftos LJ: Parathyroid hormone, thyrocal-citonins, vitamin D, bone, and bone mineral metabolism. In Duncan’s Diseases of Metabolism. Sixth edition. Edited by PK Bondy. Philadelphia, W.B. Saunders, 1969, pp 904–1082

    Google Scholar 

  36. Bernstein D, Kleeman CR, Rockney R, Dowling JT, and Maxwell MH: Studies of the renal clearance of phosphate and the role of parathyroid glands in its regulation. J Clin Endocrinol Metabol 22:641–654, 1962

    Article  CAS  Google Scholar 

  37. Levitt MF, Halpern MH, Pilimeros DP, Sweet AY, and Gribetz D: The effect of abrupt changes in plasma calcium concentrations on renal function and electrolyte excretion in man and monkey. J Clin Invest 37:294–305, 1958

    Article  CAS  Google Scholar 

  38. Schussler GC, Verso MA, and Nemoto T: Phosphaturia in hyper-calcemicbreast cancer patients. J Clin Endocrinol Metab 35:497–504, 1972

    Article  CAS  Google Scholar 

  39. DiBona GF: Effect of hypercalcemia on renal tubular sodium handling in the rat. Am J Physiol 220:49–53, 1971

    Article  CAS  Google Scholar 

  40. Beck N, Singh H, Reed SW, and Davis BB: Direct inhibitory effect of hypercalcemia on renal actions of parathyroid hormone. J Clin Invest 53:717–725, 1974

    Article  CAS  Google Scholar 

  41. Eisenberg E: Effects of serum calcium level and parathyroid extracts on phosphate and calcium excretion in hypoparathyroid patients. J Clin Invest 44:942–946, 1965

    Article  CAS  Google Scholar 

  42. Lavender AR, and Pullman TN: Changes in inorganic phosphate excretion induced by renal arterial infusions of calcium. Am J Physiol 205:1025–1032, 1963

    Article  CAS  Google Scholar 

  43. Glorieux F, and Scriver CR: Loss of a parathyroid hormone-sensitive component of phosphate transport in X-linked hypophosphatemia. Science 175:997–1000,

    Article  CAS  Google Scholar 

  44. Popovtzer MM, Robinette JB, McDonald KM, and Kuruvila CK: Effect of Ca-H- on renal handling of PO4: evidence for two reabsorptive mechanisms. Am J Physiol 229:901–906, 1975

    Article  CAS  Google Scholar 

  45. Hopkins T, Howard JE, and Eisenberg H: Ultrafiltration studies on calcium and phosphorus in human serum. Bull Johns Hopkins Hosp 91:1–21, 1952

    CAS  PubMed  Google Scholar 

  46. Rasmussen H: Ionic and hormonal control of calcium homeostasis. Am J Med 50:567–588, 1972

    Article  Google Scholar 

  47. Rasmussen H, and Tenenhouse A: Parathyroid hormone and calcitonin. In Biochemical Actions of Hormones. Vol. 1. Edited by F Litwick. New York, Academic Press, 1970, pp 365–413

    Chapter  Google Scholar 

  48. Beck N, Singh H, Reed SW, and Davis BB: Direct inhibitory effect of hypercalcemia on renal actions of parathyroid hormone. J Clin Invest 53:717–725, 1974

    Article  CAS  Google Scholar 

  49. Chase LR, Fedak SA, and Aurbach GD: Activation of skeletal adenyl cyclase by parathyroid hormone in vitro. Endocrinology 87:761–768, 1969

    Article  Google Scholar 

  50. Streeto JM: Renal cortical adenyl cyclase: effect of parathyroid hormone and calcium. Metabolism 11:968–973, 1969

    Article  Google Scholar 

  51. Bikle DD, Murphy EW, and Rasmussen H: The ionic control of 1,25-Dihydroxyvitamin D3 synthesis in isolated renal mitochondria. J Clin Invest 55:299–304, 1975

    Article  CAS  Google Scholar 

  52. Mercado A, Slatopolsky E, and Klahr S: On the mechanisms responsible for the phosphaturia of bicarbonate administration. J Clin Invest 56:1386–1395, 1975

    Article  CAS  Google Scholar 

  53. Beck LH, and Goldberg M: Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calicum, and phosphate. Am J Physiol 224:1136–1142, 1973

    Article  CAS  Google Scholar 

  54. Rector FC, Carter NW, and Seidin DW: The mechanism of bicarbonate reabsorption in the proximal and distal tubules of the kidney. J Clin Invest 44:278–290, 1965

    Article  CAS  Google Scholar 

  55. Bank N, Aynedjian HS, Weinstein SW: A microperfusion study of phosphate reabsorption by the rat proximal renal tubule. Effect of parathyroid hormone. J Clin Invest 54:1040–1048, 1974

    Article  CAS  Google Scholar 

  56. Baumann K, Rumrich G, Papavassiliou F, and Kloss S: pH dependence of phosphate reabsorption in the proximal tubule of rat kidney. Pflugers Arch 360:183–187, 1975

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiology, Mayo Clinic, Rochester, Minnesota, USA

    Franklyn G. Knox, Rainer F. Greger, Florian C. Lang & Gary R. Marchand

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  1. Franklyn G. Knox
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  2. Rainer F. Greger
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  3. Florian C. Lang
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  4. Gary R. Marchand
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Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz

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© 1977 Springer Science+Business Media New York

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Knox, F.G., Greger, R.F., Lang, F.C., Marchand, G.R. (1977). Renal Handling of Phosphate: Update. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_1

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  • DOI: https://doi.org/10.1007/978-1-4613-4217-5_1

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