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Control of Behavior by Noxious Stimuli

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Handbook of Psychopharmacology

Abstract

The control of behavior by noxious stimuli has both historical and contemporary importance in behavioral pharmacology. The development of chlorpro-mazine as a treatment for psychosis stimulated a great deal of interest in the behavioral effects of drugs. The initial pharmacological studies of chlorpromazine included experiments in rats showing that it suppressed a rope-climbing response in the presence of an auditory stimulus previously associated with electric shocks (Courvoisier et al., 1953). Later, Cook and Weidley (1957) showed that chlorpromazine could suppress responses that occurred during a stimulus period preceding the delivery of an electric shock (avoidance responses) at doses that did not affect responses evoked by the shock itself (escape responses). The results obtained with these procedures led to a search for drugs that might be more effective than chlorpromazine in the treatment of psychiatric disorders, and also prompted speculation about how these drugs were acting. It was generally assumed that drugs such as chlorpromazine had selective effects on avoidance responses because they decreased fear and anxiety.

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Author information

Authors and Affiliations

  1. Laboratory of Psychobiology, Harvard Medical School, Boston, Massachusetts, USA

    W. H. Morse

  2. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, USA

    J. W. McKearney

  3. New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA

    R. T. Kelleher

Authors
  1. W. H. Morse
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  2. J. W. McKearney
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  3. R. T. Kelleher
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, USA

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, USA

    Susan D. Iversen

  3. Departments of Pharmacology and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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© 1977 Plenum Press, New York

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Morse, W.H., McKearney, J.W., Kelleher, R.T. (1977). Control of Behavior by Noxious Stimuli. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4214-4_5

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  • DOI: https://doi.org/10.1007/978-1-4613-4214-4_5

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4613-4214-4

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