Abstract
Variability in response to drug treatment often makes it difficult to evaluate the therapeutic efficacy of psychotropic drugs and to utilize them correctly in clinical practice. Over the past 30 years, such variability has led to a still-growing and rather confusing body of knowledge relating to such issues as environment, personality characteristics of patients and of doctors, attitude, expectations, and related concepts, all of which have been described as capable of influencing drug responses (Forrest et al., 1967; Freund et al., 1972; Klerman, 1963; Heimann, 1969; McNair et al, 1970a,b; Overall et al., 1969).
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Valzelli, L. (1977). Social Experience as a Determinant of Normal Behavior and Drug Effect. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4214-4_11
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