The Contribution of Ethological Techniques to the Study of Drug Effects

  • J. H. Mackintosh
  • M. R. A. Chance
  • A. P. Silverman


Centrally acting drugs, by definition, influence the function of the nervous system and therefore inevitably affect behavior, and indeed the desired effect of such drugs is, in general, alteration of behavior. In addition, many other drugs may have behavioral side effects, and a variety of adventitious substances such as solvents and pesticides have also been reported to modify the actions and outlook of those encountering them. Investigation of the action of these agents therefore includes the need to measure behavioral change. This measuring must be done both qualitatively, so that the type of behavior influenced can be recognized, and quantitatively, so that the magnitude of the effect can be estimated. The success of any procedure that is to evaluate the behavioral effects of a drug therefore depends on the ability of the procedure to discriminate among different types of behavior and on its susceptibility to accurate measurement.


Ethyl Alcohol Laboratory Mouse Golden Hamster Royal Jelly Laboratory Rodent 
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  1. Anderson, P. K., 1964, Lethal alleles in Mus Musculus. Local distribution and the evidence for the isolation of demes, Science145:177, 178.PubMedCrossRefGoogle Scholar
  2. Andrew, R. J., 1972, Changes in search behavior in male and female chicks following different doses of testosterone, Anim. Behav.20:741–750.PubMedCrossRefGoogle Scholar
  3. Barry, H., Wagner, A. R., and Miller, N. E., 1960, Effects of drugs on the rate of operant behavior during gradations in fear, Fed. Proc. Fed. Amer. Soc. Exp. Biol.19:23.Google Scholar
  4. Bateson, P. P. G., 1968, The ethological methods of observing behavior, in: The Analysis of Behavioral Change (L. Weiskranz, ed.), Munro, New York.Google Scholar
  5. Berry, R. J., 1970, The natural history of the house mouse, Field Stud.3:2, 219–262.Google Scholar
  6. Betts, T. A., Smith, J., Pidd, S., Mackintosh, J., and Harvey, P., 1976, The effects of thyrotropin-releasing hormone on measures of mood in normal women, Br. J. Clin. Pharmacol.3:469–473.PubMedGoogle Scholar
  7. Blurton-Jones, N. G., 1967, An ethological study of some aspects of social behavior of children in nursery school, in: Primate Ethology (D. Morris, ed.), Weidenfeldt & Nicholson, London.Google Scholar
  8. Blurton-Jones, N. G., 1972, Characteristics of ethological studies of human behaviour, in: Ethological Studies of Child Behaviour (N. G. Blurton-Jones, ed.), pp. 3–37, Cambridge University Press, Cambridge.Google Scholar
  9. Boissier, J. R., and Simon, P., 1962, La réaction d’exploration chez la souris, Therapie17:1225–1232.PubMedGoogle Scholar
  10. Bovet, D., Bovet-Nitti, F., and Oliverio, A., 1967, Action of nicotine on spontaneous and acquired behavior in rats and mice, Ann. N. Y. Acad. Sci.142:261–267.CrossRefGoogle Scholar
  11. Brannigan, C. R., and Humphries, D. A., 1972, Human non-verbal behavior, a means of communication, in: Ethological Studies of Child Behavior (N. G. Blurton-Jones, ed.), pp. 37–64, Cambridge University Press, London and New York.Google Scholar
  12. Calhoun, J. B., 1948, Mortality and movement of brown rats (R. Norvegicus), J. Wild. Manage.12:167–171.CrossRefGoogle Scholar
  13. Carlini, E. A., Karniol, I. G., Renault, P. F., and Schuster, C. R., 1974, Effects of marihuana on laboratory animals and on man, Br. J. Pharmacol.50:299–309.PubMedGoogle Scholar
  14. Chance, M. R. A., 1963, A biological perspective on convulsions, Colloq. Int. C. N. R. S. (J. Busnel, ed.), p. 12, Paris.Google Scholar
  15. Chance, M. R. A., 1968, Ethology and psychopharmacology, in: Psychopharmacology: Dimensions and Perspectives (C. R. B. Joyce, ed.), Tavistock, London; Lippincott, U.S.A. and Canada.Google Scholar
  16. Chance, M. R. A., and Mead, A. P., 1955, Competition between feeding and investigation in the rat, Behaviour8:2–13.CrossRefGoogle Scholar
  17. Chance, M. R. A., and Silverman, A. P., 1964, The structure of social behaviour and drug action, in: Animal Behaviour and Drug Action (H. Steinberg, ed.), pp. 65–79, J. A. Churchill, London.Google Scholar
  18. Chance, M. R. A., Mackintosh, J. H., and Dixon, A. K., 1973, The effects of ethyl alcohol on social encounters between mice. J. Alcoholism8:90–93.Google Scholar
  19. Christiansen, H. L., Freudenthal, R. I., Gidley, J. T., Rosenfeld, R., Boegli, G., Testino, L., Brine, D. R., Pitt, C. G., and Wall, M. E., 1971, Activity of delta-8-and delta-9-tetrahydrocannabinol and related compounds in the mouse, Science172:165–167.CrossRefGoogle Scholar
  20. Clark, M. C. G., 1969, Self-administered nicotine solutions preferred to placebo by the rat, Br. J. Pharmacol.35:367.Google Scholar
  21. Cook, L., 1964, Effects of drugs on operant conditioning, in: Animal Behavior and Drug Action (Ciba Found. Symp.) (A. V. S. et Reuch and J. Knight, eds.), pp. 23–43, Little, Brown and Co., Boston, Massachusetts.Google Scholar
  22. Cook, L., and Weidley, E., 1957, Behavioral effects of some psychopharmacological agents, in: The Pharmacology of Psychotomimetic and Psychotherapeutic Drugs, Ann. N. Y. Acad. Sci.66:3, 740–752.CrossRefGoogle Scholar
  23. Crowcroft, P., and Rowe, F. P., 1963, Social organization and territorial behaviour in the wild house mouse (Mus musculus L), Proc. Zool. Soc. London140:517–531CrossRefGoogle Scholar
  24. Cutler, M. G., and Mackintosh, J. H., 1975, Effects of delta-9-tetrahydrocannabinol on social behaviour in the laboratory mouse and rat, Psychopharmacologia Berlin44:287–289.PubMedCrossRefGoogle Scholar
  25. Cutler, M. G., Mackintosh, J. H., and Chance, M. R. A., 1975a, Effects of the environment on the behavioural response of mice to nonataxic doses of ethyl alcohol, Neuropharmacology14:841–846.PubMedCrossRefGoogle Scholar
  26. Cutler, M. G., Mackintosh, J. H., and Chance, M. R. A., 1975b, Effects of cannabis resin on the social behaviour of the laboratory mouse, Psychopharmacologia Berlin41:271–276.PubMedCrossRefGoogle Scholar
  27. Dawkins, R., 1971, A cheap method of recording behavioural events for direct computer-access, Behaviour40:162–173.CrossRefGoogle Scholar
  28. Dews, P. B., 1958, Effect of chlorpromazine and promazine on performance on a mixed schedule of reinforcement, J. Exp. Anal. Behav.1:1, 73–82.PubMedCrossRefGoogle Scholar
  29. Dews, P. B., and Morse, W. H., 1961, Behavioural pharmacology, Annu. Rev. Pharmacol.1:145–174.CrossRefGoogle Scholar
  30. Dixon, A. K., and Mackintosh, J. H., 1971, Effects of female urine on the social behaviour of adult male mice, Anim. Behav.19:138–140.CrossRefGoogle Scholar
  31. Dixon, A. K., and Mackintosh, J. H., 1975, The relationship between the physiological condition of female mice and the effect of their urine on the social behavior of males, Anim. Behav.23:513–520.PubMedCrossRefGoogle Scholar
  32. Domino, E. F., 1967, EEG and behavioral arousal effects of small doses of nicotine, Ann. N.Y. Acad. Sci.142:216–244.CrossRefGoogle Scholar
  33. Eckman, P., and Friesen, W. V., 1974, Nonverbal behavior and psychopathology, in: The Psychology of Depression: Contemporary Theory and Research ( Friedman and Katz, eds.), pp. 203–224, Winstone and Riley, Washington.Google Scholar
  34. Eibl-Eibesfeldt, I., 1968, Zur Ethologie des menschlichen Grussverhaltens: I. Beobachtungen in Belinesen, Papuas und Samoanem nebst vergleichenden Bemerkungen, Z. Tierpsychol.25:727–744.PubMedCrossRefGoogle Scholar
  35. Eibl-Eibesfeldt, I., 1970, Ethology, The Biology of Behaviour, pp. 398–421, Holt, Rinehart and Winston, New York.Google Scholar
  36. Fentress, J. C., 1973, Interaction between specific and nonspecific factors in the causation of behaviour—a conceptual-operations approach, in: Perspectives in Ethology (P. P. G. Bateson and P. B. Klopfer, eds.), pp. 155–224, Plenum Press, New York.Google Scholar
  37. Fortuna, M., and Gandelman, R., 1972, Elimination of pain-induced aggression in male mice following olfactory bulb removal, Physiol. Behav.9:397–400.PubMedCrossRefGoogle Scholar
  38. Grant, E. C., 1963, An analysis of the social behaviour of the male laboratory rat, Behaviour21:260–281.CrossRefGoogle Scholar
  39. Grant, E. C., 1968, An ethological description of nonverbal behaviour during interviews, Br. J. Med. Psychol.41:177–184.PubMedCrossRefGoogle Scholar
  40. Grant, E. C., 1969, Human facial expression, Man4:525–536.CrossRefGoogle Scholar
  41. Grant, E. C., and Mackintosh, J. H., 1963, A description of the social postures of some common laboratory rodents, Behaviour21:246–259.CrossRefGoogle Scholar
  42. Grant, E. C., Mackintosh, J. H., and Lerwill, C. J., 1970, The effect of a visual stimulus on the agonistic behaviour of the golden hamster, Z. Tierpsychol.27:73–77.CrossRefGoogle Scholar
  43. Grunfeld, Y., and Edery, H., 1969, Psychopharmacological activity of the active constituents of hashish and some related cannabinoids, Psychopharmacologia Berlin14:200–210.PubMedCrossRefGoogle Scholar
  44. Halberg, F., and Barnum, C. P., 1958, Twenty-four-hour rhythms at several levels of integration in mice on different lighting regimes, Proc. Soc. Exp. Biol. Med.97:897–900.PubMedGoogle Scholar
  45. Hall, C. S., 1934, Drive and emotionality: Factors associated with adjustment in the rat, J. Comp. Physiol. Psychol.17:89–108.Google Scholar
  46. Hall, G. M., and Morrison, C. F., 1973, New evidence for a relationship between tobacco smoking, nicotine dependence, and stress, Nature London243:5404, 199–201.PubMedCrossRefGoogle Scholar
  47. Kilby, M. M., Fritchie, G. E., Mclendon, D. M., and Johnson, K. M., 1972, Attack behaviour in mice inhibited by delta-9-tetrahydrocannabinol, Nature London238:463–465.CrossRefGoogle Scholar
  48. Krsiak, M., and Borgosova, M., 1972, Drugs and spontaneous behaviour: Why are detailed studies still so rare? Act. Nerv. Super. Praha14:285–293.PubMedGoogle Scholar
  49. Krsiak, M., and Borgosova, M., 1973a, Aggression and timidity induced in mice by isolation, Act. Nerv. Super. Praha15:21, 22.Google Scholar
  50. Krsiak, M., and Janků, I., 1971, Measurement of pharmacological depression of exploratory activity in mice: A contribution to the problem of time economy and sensitivity, Psychopharmacologia21:2, 118–130.PubMedCrossRefGoogle Scholar
  51. Lowe, S., 1946, Studies of the pharmacology and acute toxicity of compounds with marihuana activity, J. Pharmacol. Exp. Ther.88:154–161.Google Scholar
  52. Mackintosh, J. H., 1965, Analysing results by computer, Proc. ASAB, Anim. Behav.13:586.CrossRefGoogle Scholar
  53. Mackintosh, J. H., 1966, Social Behaviour in the Laboratory Mouse, Ph.D. Thesis, University of Birmingham.Google Scholar
  54. Mackintosh, J. H., 1970, Territory formation by laboratory mice, Anim. Behav.18:177–183.CrossRefGoogle Scholar
  55. Mackintosh, J. H., 1973, Factors affecting the recognition of territory boundaries by mice (Mus Musculus), Anim. Behav.21:464–470.CrossRefGoogle Scholar
  56. Mackintosh, J. H., and Grant, E. C., 1966, The effects of olfactory stimuli on the agonistic behaviour of laboratory mice, Z. Tierpsychol.23:584–587.PubMedCrossRefGoogle Scholar
  57. Mcgill, T. E., 1962, Sexual behavior in three inbred strains of mice, Behaviour19:341.CrossRefGoogle Scholar
  58. Mcgill, T. E., 1965, Studies of the sexual behavior of male laboratory mice: Effect of genotype, recovery of sex drive, and theory, in: Sex and Behavior (F. A. Beach, ed.), p. 76, Wiley, New York.Google Scholar
  59. Mckennel, A. C., and Thomas, R. K., 1967, Adults and adolescents: Smoking habits and attitudes, Government social survey, H. M. Stationery Office.Google Scholar
  60. Mechoulam, R., 1973, Marihuana: Chemistry, Pharmacology, Metabolism and Clinical Effects (R. Mechoulam, ed.), Academic Press, London.Google Scholar
  61. Miller, N. E., 1964, The analysis of motivational effects illustrated by experiments on amylobarbitone sodium, in: Animal Behaviour and Drug Action (Ciba Found. Symp.) (H. Steinberg, ed.), Churchill, London.Google Scholar
  62. Morrison, C. K., and Armitage, A. K., 1967, Effect of nicotine upon the free operant behavior of rats and spontaneous motor activity of mice, Ann. N. Y. Acad. Sci.142:268–276.CrossRefGoogle Scholar
  63. Mugford, R. A., and Nowell, N. W., 1970, Pheromones and their effect on aggression in mice, Nature London226:967, 968.Google Scholar
  64. Noirot, E. B., 1958, Analyse du comportement dite maternelle chez la souris, Monogr. Fr. Psychol., 1.Google Scholar
  65. Noirot, E. B., 1965, Changes in responsiveness to young in the adult mouse: III. The effect of immediately preceding performances, Behaviour24:318–325.PubMedCrossRefGoogle Scholar
  66. Noirot, E. B., 1969, Serial order of maternal responses in mice, Anim. Behav.17:547–550.PubMedCrossRefGoogle Scholar
  67. Payne, A. P., and Swanson, H. H., 1972, The effect of a supra-normal threat stimulus on the growth rates and dominance relationships of pairs of males and female golden hamsters, Behaviour42:1, 2.CrossRefGoogle Scholar
  68. Posluns, D., 1962, Analysis of chlorpromazine-induced suppression of the avoidance response, Psychopharmacologia3:326–342.CrossRefGoogle Scholar
  69. Santos, M., Sampio, M. R. P., Fernandes, N. S., and Carlini, E. A., 1966, Effects of Cannabis sativa (marihuana) on the fighting behaviour of mice, Psychopharmacologia Berlin8:437–444.PubMedCrossRefGoogle Scholar
  70. Schechter, M. D., and Rand, M. J., 1974, Effect of acute depreciation of smoking on aggression and hostility, Psychopharmacologia35:1, 19–29.CrossRefGoogle Scholar
  71. Siegel, R. K., and Poole, J., 1969, Psychedelic-induced social behaviour in mice: A preliminary report, Psychol. Rep.25:704–706.PubMedCrossRefGoogle Scholar
  72. Silverman, A. P., 1965, Ethological and statistical analysis of drug effects on social behaviour of laboratory rats, Br. J. Pharmacol.24:579–590.Google Scholar
  73. Silverman, A. P., 1966a, The social behaviour of laboratory rats and the action of chlorpromazine and other drugs, Behaviour27:1–38.PubMedGoogle Scholar
  74. Silverman, A. P., 1966b, Barbiturates, lysergic acid diethylamide and the social behaviour of laboratory rats, Psychopharmacologia10:155–171.PubMedCrossRefGoogle Scholar
  75. Silverman, A. P., 1971, Behaviour of rats given a “smoking dose” of nicotine, Anim. Behav.19:67–74.PubMedCrossRefGoogle Scholar
  76. Silverman, A. P., and Williams, H., 1975, Behavior of rats exposed to trichloroethylene vapour, Br. J. Ind. Med.32:308–315.PubMedGoogle Scholar
  77. Silverstone, T., and Turner, P., 1974, Drug Treatment in Psychiatry, Routledge and Kegan Paul, London and Boston.Google Scholar
  78. Speizer, Z., and Weinstock, M., 1973, Influence of propanolol on abnormal behaviour induced in rats by prolonged isolation—an animal model for mania?, Br. J. Pharmacol.48:348–349.Google Scholar
  79. Steinberg, H., Rushton, R., and Tinson, C., 1961, Modification of the effects of an amphetamine-barbiturate mixture, by past experience of rats, Nature London192:533–535.PubMedCrossRefGoogle Scholar
  80. Steiniger, F., 1950, Beiträge zur Soziologie und sonstigen Biologie der Wanderratte, Z. Tierpsychol.7:356–379.CrossRefGoogle Scholar
  81. Ten Ham, M., and van Noordwijk, J., 1973, Lack of tolerance to the effects of two tetrahydrocannabinols on aggressiveness, Psychopharmacologia Berlin29:171–176.PubMedCrossRefGoogle Scholar
  82. Thiessen, D. D., Yale, P. I., and Owen, K., Identification of a ventral scent-marking pheromone in the male Mongolian gerbil (Meriones unguiculatus), Science184:83–85.Google Scholar
  83. Van Oortmerssen, G. A., 1971, Biological significance, genetics and evolutionary origin of variability in behaviour with and between inbred strains of mice, Behaviour38:1–92.PubMedCrossRefGoogle Scholar
  84. Weipkema, P., 1961, An ethological analysis of the reproductive behaviour of the bitterling, Arch. Need. Zool.14:103–199.CrossRefGoogle Scholar
  85. Weipkema, P., 1968, Behaviour changes in CBA mice as a result of one gold thioglucose injection, Behaviour32:179–210.CrossRefGoogle Scholar
  86. White, R. E. C., 1971, WRATS: A computer compatible system for automatically recording and transcribing behavioural data, Behaviour40:135–161.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. H. Mackintosh
    • 1
  • M. R. A. Chance
    • 1
  • A. P. Silverman
    • 2
  1. 1.Sub-Department of EthologyUniversity of BirminghamBirminghamEngland
  2. 2.Central Toxicology LaboratoryImperial Chemical Industries Ltd.CheshireEngland

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