Histocompatibility Antigens

  • Raymond N. Hiramoto
  • Vithal K. Ghanta

Abstract

Human leukocyte antigens (HL-A) can be used to type an individual just as he can be typed by the ABO antigens on his erythrocytes. HL-A antigens are determined by the genes on a single pair of chromosomes (chromosome 6) that occupy a region defined as the HL-A complex. The HL-A gene complex can be divided into two regions, as is true of the genetic loci for the H-2 system in the mouse (Fig. 1). Each sublocus of human HL-A carries a series of alternative alleles that appear to be codominant. Within a family, a given sublocus 1 (LA) determinant will always travel with the same sublocus II (Four) determinant. An individual can have only two to four specificities, each of which is controlled by many alleles. To date, 14 LA and 26 Four antigens and their corresponding alleles have been identified. Table I lists some of these antigens and alleles; a more extensive listing is given by Kissmeyer-Nielsen et al (1972). Examples of the possible inheritance patterns of HL-A antigens are shown in Fig. 2.

Keywords

Sucrose Electrophoresis Fractionation Leucine Mannitol 

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Raymond N. Hiramoto
    • 1
  • Vithal K. Ghanta
    • 1
  1. 1.Department of MicrobiologyUniversity of Alabama in BirminghamBirminghamUSA

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