Skip to main content
SpringerLink
Log in

Immunochemistry of Collagen

  • Chapter
Immunochemistry of Proteins

Abstract

Vertebrate collagen (Fig. IB) is made up of three polypetide chains (designated α-chains), each of about 1000 amino acid residues and having a molecular weight of about 95,000. Each chain is coiled in a left-handed helix, and the three chains are coiled in a right-handed superhelix. The triple-stranded, coiled-coil structure is rod shaped, having the dimensions of 3000 x 15 Å. Chemical studies established that the three component polypeptide chains extend in parallel the full length of the molecule.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arnon, R., and Sela, M., 1960, Biochem. J. 75: 103.

    PubMed  CAS  Google Scholar 

  • Becker, U., Timpl, R., and Kühn, K., 1972, Eur. J. Biochem. 28: 221.

    PubMed  CAS  Google Scholar 

  • Becker, U., Furthmayr, H., and Timpl, R., 1975, Hoppe-Seyler’s Z. Physiol. Chem. 356: 21.

    CAS  Google Scholar 

  • Beil, W., Furthmayr, H., and Timpl, R., 1972, Immunochemistry 9: 779. 396

    Google Scholar 

  • Beil, W., Timpl, R., and Furthmayr, H., 1973, Immunology 24: 13.

    PubMed  CAS  Google Scholar 

  • Benjamini, E., Michaeli, D., Leung, C. Y. K., Wong, K., and Scheuenstuhl, H., 1973, Immunochemistry 10: 629.

    PubMed  CAS  Google Scholar 

  • Borek, F., Kurtz, J., and Sela, M., 1969, Biochim. Biophys. Acta 188: 314.

    PubMed  CAS  Google Scholar 

  • Bornstein, P., 1968, Science 161: 592.

    PubMed  CAS  Google Scholar 

  • Bornstein, P., 1969, Biochemistry 8: 63.

    PubMed  CAS  Google Scholar 

  • Bornstein, P., 1974, The biosynthesis of collagen, in: Annual Review of Biochemistry ( E. E. Snell, P. D. Boyer, A. Meister, and R. L. Sinsheimer, eds.), pp. 567–603, Annual Reviews Inc., Palo Alto, Calif.

    Google Scholar 

  • Bornstein, P., and Nesse, R., 1970, Arch. Biochem. Biophys. 138: 443.

    PubMed  CAS  Google Scholar 

  • Chidlow, J. W., Bourne, F. J., and Bailey, A. J., 1974, Immunology 27: 665.

    PubMed  CAS  Google Scholar 

  • Chung, E., Keele, E. M., and Miller, E. J., 1974, Biochemistry 13: 3459.

    PubMed  CAS  Google Scholar 

  • Click, E. M., and Bornstein, P., 1970, Biochemistry 9: 4699.

    PubMed  CAS  Google Scholar 

  • Cracchiolo, A., Michaeli, D., Goldberg, L. S., and Fudenberg, H. H., 1975, Clin. Immunol. Immunopathol. 3: 567.

    PubMed  Google Scholar 

  • Daniels, J. R., and Chu, G. H., 1975, J. Biol. Chem. 250: 3531.

    PubMed  CAS  Google Scholar 

  • Davison, P. F., Levine, L., Drake, M. P., Rubin, A., and Bump, S., 1967, J. Exp. Med. 126: 331.

    PubMed  CAS  Google Scholar 

  • Dehrn, P., Olsen, B., and Prockop, D., 1974, Eur. J. Biochem. 46: 107.

    Google Scholar 

  • Engl, J., Kurtz, J., Katchalski, E., and Berger, A., 1966, J. Mol. Biol. 17: 255.

    Google Scholar 

  • Epstein, E. H., Jr., 1974, J. Biol. Chem. 249: 3225.

    PubMed  CAS  Google Scholar 

  • Epstein, E. H., Jr., Scott, R. D., Miller, E. J., and Piez, K. A., 1971, J. Biol. Chem. 246: 1718.

    PubMed  CAS  Google Scholar 

  • Feldmann, M., and Basten, A., 1971, J. Exp. Med. 134: 103.

    PubMed  CAS  Google Scholar 

  • Fietzek, P. P., and Kühn, K., 1976, The primary structure of collagen, in: International Review of Connective Tissue Research, Vol. 7, Academic Press, New York, pp. 1–60.

    Google Scholar 

  • Fuchs, S., and Harrington, W. F., 1970, Biochim. Biophys. Acta 221: 119.

    PubMed  CAS  Google Scholar 

  • Fuchs, S., Maoz, A., and Sela, M., 1974a, Isr. J. Chem. 12: 681.

    CAS  Google Scholar 

  • Fuchs, S., Mozes, E., Maoz, A., and Sela, M., 1974b, J. Exp. Med. 139: 148.

    CAS  Google Scholar 

  • Furthmayr, H., and Timpl, R., 1972, Biochem. Biophys. Res. Commun. 47: 944.

    CAS  Google Scholar 

  • Furthmayr, H., and Timpl, R., 1975, Immunochemistry of collagens and procollagens, in: International Review of Connective Tissue Research, Vol. 7, Academic Press, New York, 1976, pp. 61–99.

    Google Scholar 

  • Furthmayr, H., Beil, W., and Timpl, R., 1971, FEBS Lett. 12: 341.

    PubMed  CAS  Google Scholar 

  • Furthmayr, H., Stoltz, M., Becker, U., Beil, W., and Timpl, R., 1972, Immunochemistry 9: 789.

    PubMed  CAS  Google Scholar 

  • Gallop, P. M., Blumenfeld, O. O., and Seifter, S., 1972, Structure and metabolism of connective tissue proteins, in: Annual Review of Biochemistry ( E. E. Snell, P. D. Boyer, A. Meister, and C. C. Richardson, eds.), pp. 617–672, Annual Reviews Inc., Palo Alto, Calif.

    Google Scholar 

  • Gay, S., and Adelmann, B. C., 1974, Z. Immun. Allergieforsch. 147: 315.

    Google Scholar 

  • Gay, S., Fietzek, R. P., Remberger, K., Eder, M., and Kühn, K., 1975, Klin. Wochenschr. 53: 205.

    PubMed  CAS  Google Scholar 

  • Hahn, E., and Timpl, R., 1973, Eur. J. Immunol. 3: 442.

    PubMed  CAS  Google Scholar 

  • Hahn, E., Timpl, R., and Miller E. J., 1974, J. Immunol. 113: 421.

    PubMed  CAS  Google Scholar 

  • Hahn, E., Timpl, R., and Miller, E. J., 1975a; Immunology 28: 561.

    CAS  Google Scholar 

  • Hahn, E., Nowack, H., Götze, D., and Timpl, R., 1975b, Eur. J. Immunol. 5: 288.

    CAS  Google Scholar 

  • Haimovich, J., and Sela, M., 1966, J. Immunol. 94: 388.

    Google Scholar 

  • Hopper, K., Adelmann, B. C., Gentner, G., and Gay, S., 1974, Z. Immun. Allergieforsch. 147: 316.

    Google Scholar 

  • Jasin, H. E., and Glynn, L. E., 1965a, Immunology 8: 95.

    CAS  Google Scholar 

  • Jasin, H. E., and Glynn, L. E., 1965b, Immunology 8: 260.

    CAS  Google Scholar 

  • Kang, A. H., Bornstein, P., and Piez, K. A., 1967, Biochemistry 6: 788.

    PubMed  CAS  Google Scholar 

  • Kang, A. H., and Gross, J., 1970, Biochemistry 9: 796.

    PubMed  CAS  Google Scholar 

  • Kefalides, N. A., 1970, Comparative biochemistry of mammalian basement membranes, in: Chemistry and Molecular Biology of the Intercellular Matrix ( E. A. Balazs, ed.), pp. 535–573, Academic Press, New York.

    Google Scholar 

  • Kefalides, N. A., 1974, J. Clin. Invest. 53: 403.

    PubMed  CAS  Google Scholar 

  • Kettman, J. R., Benjamini, E., Michaeli, D., and Leung, D. Y. K., 1967, Biochem. Biophys. Res. Commun. 29: 623.

    PubMed  CAS  Google Scholar 

  • Kirrane, J. A., and Glynn, L. E., 1968, Immunology of collagen, in: International Review of Connective Tissue Research (D. A. Hall, ed.), pp. 1–31, Vol. 4, Academic Press, New York.

    Google Scholar 

  • Kirrane, J. A., and Van B. Robertson, W., 1968, Immunology 14: 139.

    PubMed  CAS  Google Scholar 

  • Knapp, W., Menzel, J., Brunner, H., and Steffen, C., 1974, Z. Immun. Allergieforsch. 146: 283.

    CAS  Google Scholar 

  • Kühn, K., 1969, The structure of collagen, in: Essays in Biochemistry, Vol. 5 ( P. N. Campbell, and G. D. Greville, eds.), pp. 59–87, Academic Press, New York.

    Google Scholar 

  • Lenaers, A., Ansay, M., Nusgens, B. V., and Lapière, C. M., 1971, Eur, J. Biochem. 23: 533.

    CAS  Google Scholar 

  • LeRoy, C. E., 1968, Proc. Soc. Exp. Biol. Med. 128: 341.

    PubMed  CAS  Google Scholar 

  • LeRoy, C. E., 1969, J. Immunol. 102: 919.

    PubMed  CAS  Google Scholar 

  • Lindsley, H. B., Mannik, M., and Bornstein, P., 1969, Arthritis Rheum. 12: 676.

    Google Scholar 

  • Lindsley, H., Mannik, M., and Bornstein, P., 1971, J. Exp. Med. 133: 1309.

    PubMed  CAS  Google Scholar 

  • Maoz, A., Fuchs, S., and Michaeli, D., 1971, Biochim. Biophys. Acta 243: 106.

    PubMed  CAS  Google Scholar 

  • Maoz, A., Fuchs, S., and Michaeli, D., 1971, Biochim. Biophys. Acta 243: 106.

    PubMed  CAS  Google Scholar 

  • Maoz, A., Dym, H., Fuchs, S., and Sela, M., 1973a, Eur. J. Immunol. 3: 839.

    CAS  Google Scholar 

  • Maoz, A., Fuchs, S., and Sela, M., 1973b, Biochemistry 12: 4238.

    CAS  Google Scholar 

  • Maoz, A., Fuchs, S., and Sela M., 1973c, Biochemistry 12: 4246.

    CAS  Google Scholar 

  • Martin, G. R., Byers, P. H., and Piez, K. A., 1975, Advan. Enzymol. 42: 167.

    CAS  Google Scholar 

  • McBride, O. W., and Harrington, W. F., 1967, Biochemistry 6: 1484.

    PubMed  CAS  Google Scholar 

  • Meigel, W., Pontz, B., Timpl, R., Hieber, E., Nordwig, A., Steffen, C., and Kühn, K., 1971, J. Immunol. 107: 1146.

    PubMed  CAS  Google Scholar 

  • Michaeli, D., and Epstein, E. H., 1971, Isr. J. Med. Sci. 7: 462.

    PubMed  CAS  Google Scholar 

  • Michaeli, D., and Fudenberg, H. H., 1974a, Clin. Immunol. Immunopathol. 2: 153.

    CAS  Google Scholar 

  • Michaeli, D., and Fudenberg, H. H., 1974b, Clin. Immunol. Immunopathol. 3: 187.

    CAS  Google Scholar 

  • Michaeli, D., Kamenecka, H., Benjamini, E., Kettman, J. R., Leung, D. Y. K., and Miner, R. C., 1968, Immunochemistry 5: 433.

    CAS  Google Scholar 

  • Michaeli, D., Martin, G. R., Kettman, J., Benjamini, E., Leung, D. Y. K., and Blatt, B. A., 1969, Science 166: 1522.

    PubMed  CAS  Google Scholar 

  • Michaeli, D., Martin, G. R., and Benjamini, E., 1970, Localization of the antigenic determinants of collagen, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 1 ( E. A. Balazs, ed.), pp. 275–278, Academic Press, New York.

    Google Scholar 

  • Michaeli. D., Benjamini, E., and Leung, D. Y. K., 1971, Immunochemistry 8: 1.

    PubMed  CAS  Google Scholar 

  • Michaeli, D., Senyk, G., Maoz, A., and Fuchs, S., 1972, Immunol. 109: 103.

    CAS  Google Scholar 

  • Miller, E. J., 1971, Biochemistry 10: 1652.

    PubMed  CAS  Google Scholar 

  • Miller, E. J., Woodall, D. L., and Vail, M. S., 1973, J. Biol. Chem. 248: 1666.

    PubMed  CAS  Google Scholar 

  • Nordwig, A., Nowack, H., and Hieber-Rogall, E., 1973, J. Mol. Evol. 2: 175.

    PubMed  CAS  Google Scholar 

  • Nowack, H., Timpl, R., and Nordwig, A., 1974, Eur. J. Immunol. 4: 698.

    PubMed  CAS  Google Scholar 

  • Nowack, H., Hahn, E., David, C. S., Timpl, R., and Götze, D., 1975a, Immunogenetics 2: 331.

    Google Scholar 

  • Nowack, H., Hahn, E., and Timpl, R., 1975b, Immunology 29: 621.

    CAS  Google Scholar 

  • O’Dell, D. S., 1968, Immunology of collagen and related materials, in: Treatise on Collagen, Vol. 2 ( B. S. Gould, ed.), pp. 311–322, Part A, Academic Press, New York.

    Google Scholar 

  • Olsen, B. R., and Prockop, D. J., 1974, Proc. Natl. Acad. Sci. U.S.A. 71: 2033.

    PubMed  CAS  Google Scholar 

  • Pontz, B., Meigel, W., Rauterberg, J., and Kühn, K., 1970, Eur. J. Biochem. 16: 50.

    PubMed  CAS  Google Scholar 

  • Rauterberg, J., and Kuhn., 1971, Eur. J. Biochem. 19: 398.

    PubMed  CAS  Google Scholar 

  • Rauterberg, J., Timpl, R., and Furthmayr, H., 1972, Eur. J. Biochem. 27: 231.

    PubMed  CAS  Google Scholar 

  • Rothbard, S., and Watson, R. F., 1961, J. Exp. Med. 113: 1041.

    PubMed  CAS  Google Scholar 

  • Rothbard, S., and Watson, R. F., 1965, J. Exp. Med. 122: 441.

    PubMed  CAS  Google Scholar 

  • Rothbard, S., and Watson, R. F., 1967, J. Exp. Med. 125: 595.

    PubMed  CAS  Google Scholar 

  • Schmitt, F. 0., Levine, L., Drake, M. P., Rubin, A. L., Pfahl, D., and Davison, P. F., 1964, Proc. Natl. Acad. Sci. U.S.A. 51: 493.

    PubMed  CAS  Google Scholar 

  • Schofeld, J. D., and Prockop, D. J., 1973, Clin. Orthop. Related Res. 93: 175.

    Google Scholar 

  • Sela, M., and Arnon, R., 1960a, Biochem. J. 75: 91.

    CAS  Google Scholar 

  • Sela, M., and Arnon, R., 1960b, Biochem. J. 77: 394.

    CAS  Google Scholar 

  • Senyk, G., and Michaeli, D., 1973, J. Immunol. 111: 1381.

    PubMed  CAS  Google Scholar 

  • Sherr, C. J., and Goldberg, B., 1973, Science 180: 1190.

    PubMed  CAS  Google Scholar 

  • Stark, M., Rauterberg, J., and Kühn, K., 1971, FEBS Lett. 13: 101.

    PubMed  CAS  Google Scholar 

  • Steffen, C., 1970, Z. Immun. Allergieforsch. 139: 219.

    CAS  Google Scholar 

  • Steffen, C., Timpl, R., and Wolff, I., 1967a, Z. Immunitaetsforsch. 134: 91.

    CAS  Google Scholar 

  • Steffen, C., Timpl, R., and Wolff, I., 1967b, Z. Immunitaetsforsch. 134: 205.

    CAS  Google Scholar 

  • Steffen, C., Timpl, R., and Wolff, I., 1968a, Immunology 51: 135.

    Google Scholar 

  • Steffen, C., Schuster, F., Tausch, G., and Pecker, I., 1968b, Klin. Wochenschr. 46: 976.

    CAS  Google Scholar 

  • Steffen, C., Dichtl, M., Knapp, W., and Brunner, H., 1971, Immunology 21: 649.

    PubMed  CAS  Google Scholar 

  • Steffen, C., Ludwig, H., Thumb, N., Frank, O., Eberl, R., and Tausch, F., 1973, Klin. Wochenschr. 51: 222.

    PubMed  CAS  Google Scholar 

  • Steffen, C., Ludwig, H., and Knapp, W., 1974, Z. Immun. Allergieforsch. 147: 229.

    CAS  Google Scholar 

  • Stoltz, M., Timpl, R., and Kühn, K., 1972, FEBS Lett. 26: 61.

    CAS  Google Scholar 

  • Stoltz, M., Timpl, R., Furthmayr, H., and Kühn, K., 1973, Eur. J. Biochem. 37: 287.

    PubMed  CAS  Google Scholar 

  • Taubman, M. B., Goldberg, B., and Sherr, C. J., 1974, Science 186: 1115.

    PubMed  CAS  Google Scholar 

  • Timpl, R., Wolff, I., Furthmayr, H., and Steffen, C., 1968a, Immunology 15: 145.

    CAS  Google Scholar 

  • Timpl, R., Wolff, I., Wick, G., Furthmayr, H., and Steffen, C., 1968b, J. Immunol. 101: 725.

    CAS  Google Scholar 

  • Timpl, R., Wolff, I., Meigel, W., Pontz, B., Steffen, C., and Kühn, K., 1970, J. Immunol. 105: 1131.

    PubMed  CAS  Google Scholar 

  • Timpl, R., Beil, W., Furthmayr, H., Meigel, W., and Pontz, B., 1971, Immunology 21:1017.

    Google Scholar 

  • Timpl, R., Furthmayr, H., and Beil, W., 1972, J. Immunol. 108: 119.

    PubMed  CAS  Google Scholar 

  • Timpl, R., Furthmayr, H., Hahn, E., Becker, V., and Stoltz, M., 1973a, Behring Inst. Mitt. 53: 66.

    CAS  Google Scholar 

  • Timpl, R., Wick, G., Furthmayr, H., Lapiere, C. M., and Kühn, K., 1973b, Eur. J. Biochem. 32: 584.

    CAS  Google Scholar 

  • Tkocz, C., and Kühn, K., 1969, Eur. J. Biochem. 7: 454.

    PubMed  CAS  Google Scholar 

  • Traub, W., and Piez, K. A., 1971, The chemistry and structure of collagen, in: Advances in Protein Chemistry, Vol. 25 (C. B. Anfinsen, Jr., J. T. Edsall, and F. M. Richards, eds.), pp. 243–352, Academic Press, New York.

    Google Scholar 

  • Traub, W., and Yonath, A., 1966, J. Mol. Biol. 16: 404.

    PubMed  CAS  Google Scholar 

  • von der Mark, K„ Wendt, P., Rexrodt, F., and Kuhn, K., 1970, FEBS Lett. 11: 105.

    PubMed  Google Scholar 

  • von der Mark, K., Click, E. M., and Bornstein, P., 1973, Arch. Biochem. Biophys. 156: 356.

    PubMed  Google Scholar 

  • Watson, R. F., Rothbard, S., and Vanamee, P., 1954, J. Exp. Med. 99: 535.

    PubMed  CAS  Google Scholar 

  • Wells, J. V., Michaeli, D., and Fudenberg, H. H., 1973, Clin. Exp. Immunol. 13: 203.

    PubMed  CAS  Google Scholar 

  • Wells, J. V., Michaeli, D., and Fudenberg, H. H., 1975, Auto-immunity in selective IgA deficiency, in: Birth Defects: Original Article Series (D. Bergsma and R. A. Good, eds.), Sinauer Associates, New York, Vol. 6, No. 1, pp. 144–146.

    Google Scholar 

  • Wick, G., Furthmayr, H., and Timpl, R., 1975, Int. Arch Allergy Appl. Immunol. 48:664.

    PubMed  CAS  Google Scholar 

  • Wolff, I., Wick, G., Furthmayr, H., Timpl. R., and Steffen, C., 1970, Immunology 18: 843.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Biochemistry and Biophysics and Surgery, University of California School of Medicine, San Francisco, California, 94143, USA

    Dov Michaeli

Authors
  1. Dov Michaeli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Mayo Graduate School of Medicine, Rochester, Minnesota, USA

    M. Z. Atassi

  2. University of Minnesota, Minneapolis, Minnesota, USA

    M. Z. Atassi

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Plenum Press, New York

About this chapter

Cite this chapter

Michaeli, D. (1977). Immunochemistry of Collagen. In: Atassi, M.Z. (eds) Immunochemistry of Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4190-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4190-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4192-5

  • Online ISBN: 978-1-4613-4190-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation