Skip to main content

Control of Biochemical Parameters in Glycoprotein Production

  • Chapter
Mucus in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 89))

Abstract

The oligosaccharide prosthetic groups of glycoproteins are highly complex polymers consisting of several different monosaccharides arranged in both linear and branched arrays. The linkage between two sugars in these arrays can be either α or β and can occur between the anomeric carbon of one sugar and three to four possible carbons of the other sugar. In short, as has been frequently pointed out, the number of theoretical structures for even the shortest oligosaccharides is astronomical. As more information on glycoprotein structure becomes available (Montreuil, 1975), it is beginning to appear that although cells are capable of assembling an impressive number of different oligosaccharide structures, there are certain controlling features in the process which put definite limits on the types of structures that are made.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baenziger, J. and Kornfeld, S. (1974). J.Biol.Chem., 249, 7270.

    Google Scholar 

  • Behrens, N.H. (1974). in, Biology and Chemistry of Eucaryotic Cell Surfaces. (Eds.) E.Y.C. Lee and E.E. Smith, pp.159–180. Academic Press, N.Y.

    Google Scholar 

  • Bosmann, H.B. and Eylar, E.H. (1968). Biochem.Biophys.Res.Comm., 33, 340.

    Article  Google Scholar 

  • Brew, K., Vanaman, T.C. and Hill, R.L. (1968). Proc.Nat.Acad.Sci. U.S.A., 59, 491.

    Article  Google Scholar 

  • DeVries, A.L., Vandenheede, J. and Feeney, R.E. (1971). J.Biol. Chem., 246, 305.

    Google Scholar 

  • Eagon, P.K., Hsu, A.-F. and Heath, E.C. (1975). Federat.Procs., 34, 678.

    Google Scholar 

  • Ebner, K.E., Manwal, R., Fitzgerald, D.K. and Colvin, B. (1972a). in, Methods in Enzymology. (Ed.) V. Ginsburg. Vol.28, pp. 500–506. Academic Press, N.Y.

    Google Scholar 

  • Ebner, K.E., Manwal, R., Fitzgerald, D.K. and Colvin, B. (1972b). in, Methods in Enzymology. (Ed.) V. Ginsburg. Vol.28, pp. 507–510. Academic Press, N.Y.

    Google Scholar 

  • Hagopian, A. and Eylar, E.H. (1968). Arch.Biochem.Biophys., 128, 422.

    Article  Google Scholar 

  • Hagopian, A., Westall, F.C., Whitehead, J.S. and Eylar, E.H. (1971). J.Biol.Chem., 246, 2519.

    Google Scholar 

  • Heath, E.C., Baynes, J.W. and Hsu, A.-F. (1974). in, Biology and Chemistry of Eucaryotic Cell Surfaces. (Eds.) E.Y.C. Lee and E.E. Smith, pp. 181–211. Academic Press, N.Y.

    Google Scholar 

  • Hudgin, R.L. and Schachter, H. (1972). Can.J.Biochem., 50, 1024.

    Article  Google Scholar 

  • Marshall, R.D. (1974). Biochem.Soc.Symp., 40, 17.

    Google Scholar 

  • McGuire, E.J. (1970). in, Blood and Tissue Antigens. (Ed.) D. Aminoff. pp. 461–478. Academic Press, N.Y.

    Google Scholar 

  • McGuire, E.J., Jourdian, G.W., Carlson, D.M. and Roseman, S. (1965). J.Biol.Chem., 240, PC4113.

    Google Scholar 

  • McGuire, E.J. and Roseman, S. (1967). J.Biol.Chem., 242, 3745.

    Google Scholar 

  • Montreuil, J. (1975). Pure Appl.Chem., 42, 431.

    Article  Google Scholar 

  • Narasimhan, S., Stanley, P., Williams, D. and Schachter, H. (1976). Fed.Proc., 35, 1441.

    Google Scholar 

  • Ogata, S., Muramatsu, T. and Kobata, A. (1975). J.Biochem., 78, 687.

    Google Scholar 

  • Oliver, G.J.A., Harrison, J. and Hemming, F.W. (1975). Eur.J. Biochem., 58, 223.

    Article  Google Scholar 

  • Rodén, L., Baker, J.R., Cifonelli, J.A. and Mathews, M.B. (1972a). in, Methods in Enzymology. (Ed.) V. Ginsburg. Vol.28, pp.73–140. Academic Press, N.Y.

    Google Scholar 

  • Rodén, L., Baker, J.R., Helting, T., Schwartz, N.B., Stoolmiller, A.C., Yamagata, S. and Yamagata, T. (1972b). in, Methods in Enzymology. (Ed.) V. Ginsburg. Vol.28, pp. 638–676. Academic Press, N.Y.

    Google Scholar 

  • Schachter, H. (1974). Biochem.Soc.Symp., 40, 57.

    Google Scholar 

  • Schachter, H. and Roden, L. (1973). in, Metabolic Conjugation and Metabolic Hydrolysis. (Ed.) W.H. Fishman. Vol.3, pp. 1–149, Academic Press, N.Y.

    Google Scholar 

  • Schachter, H., McGuire, E.J. and Roseman, S. (1971). J.Biol.Chem., 246, 5321.

    Google Scholar 

  • Schwartz, N.B. and Rodén, L. (1974). Carbohyd.Res., 37, 167.

    Article  Google Scholar 

  • Spiro, R.G. and Spiro, M.J. (1971a). J.Biol.Chem., 246, 4899.

    Google Scholar 

  • Spiro, M.J. and Spiro, R.G. (1971b). J.Biol.Chem., 246, 4910.

    Google Scholar 

  • Stanley, P., Siminovitch, L., Narasimhan, S. and Schachter, H. (1975). Proc.Nat.Acad.Sci., U.S.A., 72, 3323.

    Article  Google Scholar 

  • Waechter, C.J. and Lennarz, W.J. (1976). Ann.Rev.Biochem., 45, 95.

    Article  Google Scholar 

  • Watkins, W.M. (1974). Biochem.Soc.Symp., 40, 125.

    Google Scholar 

  • Wilson, J.R., Williams, D. and Schachter, H. (1975). Biochem. Biophys.Res.Comm., 72, 909.

    Article  Google Scholar 

  • Winzler, R.J. (1973). in, Membrane-mediated Information. (Ed.) P.W. Kent. pp.3–19, Elsevier, N.Y.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Plenum Press, New York

About this chapter

Cite this chapter

Schachter, H. (1977). Control of Biochemical Parameters in Glycoprotein Production. In: Elstein, M., Parke, D.V. (eds) Mucus in Health and Disease. Advances in Experimental Medicine and Biology, vol 89. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4172-7_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4172-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4174-1

  • Online ISBN: 978-1-4613-4172-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics