Abstract
Mucosal cells of the gastrointestinal tract are rich in glycoprotein. Cellular glycoproteins can be broadly classified into two types: secretory and structural. An example of the former are the intestinal cell mucins, while the latter type are structural components of cell surface membranes and of the membranes of various subcellular organelles. Ample data are available that implicate the membrane glycoproteins and glycolipids as important elements in certain cellular phenomena which undergo alterations during cancerous transformation. These include cell-cell interaction, growth regulation, agglutinability by lectins, and immunological reactivity of cell surface antigens (Aaronson and Todaro, 1968; Burger and Goldberg, 1967; Gold, et al 1968). Therefore, we are currently investigating both secretory and structural glycoproteins in normal and cancerous tissues taken from the colonic mucosa of man and experimental animals. The present report describes some of the data that we have obtained on the blood group activity, lectin reactivity and the carbohydrate composition of the membrane glycoproteins of normal and cancerous human colonic mucosa. The possible metabolic bases for the observed alterations in immunochemical and chemical properties of the glycoproteins in colonic cancer tissues were also - examined by studying various enzymes thought to be involved in the synthesis and degradation of glycoproteins.
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Kim, Y.S. (1977). Glycoprotein Alteration in Human Colonic Adenocarcinoma. In: Elstein, M., Parke, D.V. (eds) Mucus in Health and Disease. Advances in Experimental Medicine and Biology, vol 89. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4172-7_30
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DOI: https://doi.org/10.1007/978-1-4613-4172-7_30
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