Rosette Formation in Chicks: With Special Reference to QRBC-Rosettes

  • Koji Sato
  • Makoto Itoh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 88)


The significance of rosette forming cells (RFC) has been well documented in the basic and clinical fields of immunology. In general, sheep red blood cells (SRBC) are extensively used as an indicator of the cells. It was reported, however, that lymphoid cells of chicks formed spontaneous rosettes more efficiently with RBCs of several species of birds as compared with any of the RBCs including those from carp, bull frogs, snakes and some mammals examined [1]. Among the RBCs of birds, Japanese quail RBC (QRBC) formed the highest number of rosettes (QRBC-rosettes) in the bone marrow and spleen. On the other hand, it was difficult to detect them in the thymus and peripheral blood lymphocytes (PBL).


Peripheral Blood Lymphocyte Lymphoid Cell Test Mixture Rosette Formation Cortisone Acetate 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Koji Sato
    • 1
  • Makoto Itoh
    • 1
  1. 1.Department of Animal PhysiologyNagoya UniversityNagoyaJapan

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