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Pathways of UV Repair and Mutagenesis in Saccharomyces cerevisiae

  • B. S. Cox

Abstract

Starting in 1967 with work published by Nakai1 a number of workers have isolated in the yeast Saccharomyces cerevisiae, mutants which were more than usually sensitive to treatment with mutagens2, 3, 4, 5, 6. Generally, the phenotype sought was sensitivity to ultra violet light of 254 nm wavelength, but many of the mutants were found also to be sensitive to other mutagens, such as ionising radiation1, 3, 4, 6, 7 or chemicals7. These mutants fell into a rather large number of different loci8, 9, at least twenty-two conferring UV-sensitivity when mutant and a further eight loci primarily determining resistance to ionising radiation. Subsequently, mutants isolated with othey phenotypes such as resistance to UV-induced mutation10 or sensitivity to methyl-methane sulphonate (Snow, unpublished) were also found to be UV-sensitive. In some cases, these mutations had occurred at loci different from those previously identified.

Keywords

Repair Pathway Mutational Lesion Ochre Mutation Dime Excision Triple Mutant Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • B. S. Cox
    • 1
  1. 1.Botany SchoolOxford UniversityOxfordUK

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