Photochemotherapy of Psoriasis (PUVA)

  • Klaus Wolff


This paper reviews photochemotherapy (PUVA) in over 300 patients with severe, generalized psoriasis, covering a follow-up period of up to two years. Results of treatment, side effects and laboratory studies are described and the principles, theoretical background, and optimum conditions of this treatment are discussed.


Sister Chromatid Exchange Lichen Planus Mycosis Fungoides Uninvolved Skin PUVA Treatment 
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  1. 1.
    J. A. Parrish, T. B. Fitzpatrick, L. Tanenbaum, and M.A. Pathak, Photo-chemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light, New Engl.J.Med. 291, 1207–1211 (1974).CrossRefGoogle Scholar
  2. 2.
    K. Wolff, H. Hönigsmann, F. Gschnait, and K. Konrad, Photochemotherapie bei Psoriasis. Klinische Erfahrungen bei 152 Patienten, Dt.Med. Wschr. 48, 2471–2477 (1975).CrossRefGoogle Scholar
  3. 3.
    K. Wolff, T.B. Fitzpatrick, J.A. Parrish, F. Gschnait, B. Gilchrest, H. Hönigsmann, M.A. Pathak, and L. Tanenbaum,Photo-chemotherapy of psoriasis with oral 8-methoxypsoralen, Arch.Derm.(Chic.) 112, 943–950 (1976).Google Scholar
  4. 4.
    H.O. Perry, C.W. Soderström, and R.W. Schulze, The Goeckerman treatment of psoriasis, Arch.Derm (Chic), 98, 178–182 (1968).Google Scholar
  5. 5.
    H. Tronnier and D. Schüle, First results of therapy with longwave UV after photosensitization of skin, Book of Abstracts, Symposia, and Contributed Papers, 6th International Congress of Photobiology, Bochum, Germany, GO Schenck,ed. 1972.Google Scholar
  6. 6.
    S.M.A. Mortazawi and H. Oberste-Lehn, Lichtsensibilisatoren und ihre therapeutischen Fähigkeiten, 1. vorläufige Mitteilung. Z. Hautkr, 48, 1–9 (1973).Google Scholar
  7. 7.
    H. Tronnier and D. Schüle, Zur Therapie von Dermatosen mit langwelligem UV nach Photosensibilisierung der Haut mit Methoxsalen. Z.Hautkr, 48, 385–393 (1973).Google Scholar
  8. 8.
    G. Weber, Combined 8-methoxypsoralen and blacklight therapy of psoriasis, Brit.J.Derm., 90, 317–323 (1).Google Scholar
  9. 9.
    H. Oberste-Lehn and S.M.A. Mortazawi, Therapeutische Ergebnisse bei der Anwendung von 8-Methoxypsoralen (MOP) und UV-A Z. Hautkr, 50, 559–751 (1975).Google Scholar
  10. 10.
    H. Tronnier and R. Löhning, About the current status of methoxsalen-UV-A-therapy in Dermatology. Castellania, 2, 267–271 (1974).Google Scholar
  11. 11.
    K. Wolff, F. Gschnait, H. Hönigsmann, K. Konrad, G. Strügl, E. Wolff-Schreiner and P. Fritsch, Oral Photo-chemotherapy-results, follow-up, and pathology, Proceedings of the Second International Symposium on Psoriasis, Stanford, July 12–159 (1976), Plenum Press, in press.Google Scholar
  12. 12.
    G. Swanbeck, M. Thyresson-Hök, A. Bredberg, and B. Lambert, Treatment of psoriasis with oral psoralens and longwave ultraviolet light. Acta Dermatovener (Stockholm) 55, 367–376 (1975).Google Scholar
  13. 13.
    C. Hofmann, G. Plewig, and O. Braun-Falco, Technische Erfahrungen mit der 8-Methoxypsoralen-Photochemotherapie bei Psoriasis vulgaris, Hautarzt, 27, 277–285, (1976).Google Scholar
  14. 14.
    K. Weisman, J. Howitz, and A. Bro-Jorgensen, Treatment of psoriasis with 8-methoxypsoralen and longwave ultraviolet light (PUVA). Clinical Medicine 4, 28, (1976).Google Scholar
  15. 15.
    H. Tronnier and H. Heidbüchel, Zur Therapie der Psoriasis vulgaris mit ultravioletten Strahlen. Z. Hautkr. 51, 405–424, (1976).Google Scholar
  16. 16.
    K. Wolff, F. Gschnait, H. Hönigsmann, K. Konrad, J.A. Parrish and T.B. Fitzpatrick, Phototesting and dosimetry for Photo-chemotherapy. Brit. J Dermatol, in press.Google Scholar
  17. 17.
    F. Gschnait, K. Konrad, H. Hönigsmann, and K. Wolff, Photo-chemotherapy in cortocosteroid- and methotrexate-treated psoriatics. Hautarzt, in press.Google Scholar
  18. 18.
    R.S. Cole, Light-induced cross-linking of DNA in the presence of a furocumarin (psoralen), Biochim Biophys Acta 217, 30–39, (1970).Google Scholar
  19. 19.
    F. Dall’Acqua, S. Marciani, L. Ciavatta et al, Formation of interstrand crosslinks in the photoreactions between furocomarins and DNA, Z Naturforsch 26, 561–569, (1971).Google Scholar
  20. 20.
    M.A. Pathak, D.M. Kramer, and T.B. Fitzpatrick, Photobiology and photochemistry of furocumarins (psoralens), in Pathak MA, Harber IG, Seiji M, et al, (eds.): Sunlight and Man: Normal and Abnormal Photobiologic Responses. Tokyo, University of Tokyo Press, pp 335–368, (1974).Google Scholar
  21. 21.
    J.H. Epstein, and K. Fukuyama, A study of 8-methoxypsoralen- induced phototoxic effects on mammalian epidermal macromolecule synthesis in vivo. Photochem Photobiol 21, 325–330, (1975).CrossRefGoogle Scholar
  22. 22.
    H.P. Baden, J.M. Parrington, J.D.A. Delhanty, et al, DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and longwave ultraviolet light. Biochim Biophys Acta 262: 247–255, (1972).Google Scholar
  23. 23.
    M.J. Ashwood-Smith and E. Grant: Chromosome damage produced by psoralen and ultraviolet light. Brit Med.J, 272, (1976).Google Scholar
  24. 24.
    D.M. Carter, K. Wolff, and W. Schnedl, 8-methoxypsoralen and UV-A promote sister chromatid exchanges. J Invest Dermatol, in press.Google Scholar
  25. 25.
    E. Wolff-Schreiner, D.M. Carter, W. Schnedl, and K. Wolff, Sister chromatid exchanges in psoriasis patients treated with Photo-chemotherapy, J Invest Derm., in press.Google Scholar
  26. 26.
    J.F. Walter, J.J. Voorhees, W.H. Kelsey, et al, Psoralen plus black light inhibits epidermal DNA synthesis, Arch Dermatol, 107, 861–865, (1973).CrossRefGoogle Scholar
  27. 27.
    O. Braun-Falco and E. Christophers, Structural aspects of initial psoratic lesions, Arch.Derm.Forsch. 251, 95–99, (1974).Google Scholar
  28. 28.
    H. Hönigsmann, K. Konrad, F. Gschnait, and K. Wolff, Photo-chemotherapy of mycosis fungoides, VII International Congress on Photobiology, August 29–September 3, (1976), Rome, Book of Abstracts, P 222.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Klaus Wolff
    • 1
  1. 1.Department of DermatologyUniversity of InnsbruckInnsbruckAustria

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