Postreplication Repair in Human Fibroblasts

  • A. R. Lehmann
  • S. Kirk-Bell
  • C. F. Arlett

Summary

Postreplication repair is defective in fibroblasts from all the xeroderma pigmentosum (XP) complementation groups with the exception of group E, the defect being most pronounced in the excision-proficient XP variants. It is normal in cells from patients with a variety of other disorders. During postreplication repair pyrimidine dimer sites become associated with daughter strands in both normal and XP cells.

Keywords

Sucrose Sedimentation Caffeine Pyrimidine Thymidine 

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • A. R. Lehmann
    • 1
  • S. Kirk-Bell
    • 1
  • C. F. Arlett
    • 1
  1. 1.MRC Cell Mutation UnitUniversity of SussexFalmer, BrightonEngland

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