Summary
Using GC-MS a N-acetylated amino acid, 2-n-propyl-3-(N-acetylamino)pentanoic acid, was identified in the urine from rats treated with sodium dipropylacetate (DPA).
The urinary contents of β-alanine and methylated 4-amino-5-imidazole-carboxylate were found to be much more abundant in the urine of DPA-treated rats than the controls by the technique of GC-MF.
The N-acetylated amino acid and part of β-alanine may originate from DPA via the metabolic intermediate of β-oxidation, but the reason for the elevated excretion of methylated 4-amino-5-imidazolecarboxylate, degradation product of methylated purine bases, is not clear.
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References
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© 1977 Plenum Press, New York
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Matsumoto, I., Kuhara, T., Yoshino, M., Tetsuo, M. (1977). Formation of a New Amino Acid as a Metabolic Intermediate of Sodium Dipropylacetate. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_6
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DOI: https://doi.org/10.1007/978-1-4613-4151-2_6
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