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Screening by Gas Chromatography-Mass Spectrometry for Metabolites of Five Commonly Used Anabolic Steroid Drugs

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Mass Spectrometry in Drug Metabolism

Summary

A gas chromatographic-mass spectrometry (GC-MS) technique is described for the detection and identification of anabolic steroid drugs in urine samples of athletes competing in major international events.

The metabolism of some commonly used drugs, in particular, Dianabol (17α-methyl-1,4-androstadien-17ß-o1-3-one), Stanazolol (17α-methyl-5α-androstan-17ß-o1-[ 3,2-c ]-pyrazole), Nilevar (17α-ethyl-4-estren-17ß-o1-3-one), Orabolin (17α-ethyl-4-estren-17ß-o1), Durabolin (4-estren-17ß-o1-3-one phenylpropionate) have been studied. The approach to processing the data from the GC-MS analysis does not preclude the detection of other additional anabolic steroid drugs.

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References

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Author information

Authors and Affiliations

  1. Division of Clinical Chemistry, Clinical Research Centre, Watford Road, Harrow, Middlesex, HAl 3UJ, England

    R. J. Ward, A. M. Lawson & C. H. L. Shackleton

Authors
  1. R. J. Ward
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  2. A. M. Lawson
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  3. C. H. L. Shackleton
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Editor information

Editors and Affiliations

  1. “Mario Negri” Institute for Pharmacological Research, Milan, Italy

    Alberto Frigerio

  2. Department of Organic Chemistry, University of Western Australia, Nedlands, Western Australia, Australia

    Emilio L. Ghisalberti

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© 1977 Plenum Press, New York

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Ward, R.J., Lawson, A.M., Shackleton, C.H.L. (1977). Screening by Gas Chromatography-Mass Spectrometry for Metabolites of Five Commonly Used Anabolic Steroid Drugs. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_31

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  • DOI: https://doi.org/10.1007/978-1-4613-4151-2_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4153-6

  • Online ISBN: 978-1-4613-4151-2

  • eBook Packages: Springer Book Archive

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