Abstract
Since the pioneering work of the Millers (1) and Magee and Barnes (2), it has become increasingly evident that many stable chemicals are metabolized to electrophilic intermediates that alkylate and arylate tissue macromolecules. This laboratory (3–5) has shown that drugs, such as acetaminophen (paracetamol), phenacetin, furosemide (frusemide), isoniazid, and iproniazid, also are oxidatively activated by microsomal enzymes to electrophilic intermediates that covalently bind to tissue macromolecules and cause massive tissue necrosis.
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© 1977 Plenum Press, New York
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Nelson, S.D., Mitchell, J.R., Pohl, L.R. (1977). Application of Chemical Ionization Ms and the Twin-Ion Technique in the Analysis of Reactive Intermediates in Drug Metabolism. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_18
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DOI: https://doi.org/10.1007/978-1-4613-4151-2_18
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