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MHPG, Amitriptyline and Depression: A Collaborative Study

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Mass Spectrometry in Drug Metabolism

Abstract

A large body of clinical pharmacological data seems to be consistent with the existence of a relationship, perhaps causal, between abnormalities of catecholamine metabolism and affective disorders. This point of view has been formally organized into a “catecholamine hypotheses of affective disorders” (1–6), which differ in detail, but all present the view that depression is associated with a functional deficit in the amount of catecholamines available at the site of the receptor of critical central synapses.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University of Milan, Milan, Italy

    E. Allaria

  2. School of Veterinary Medicine, University of Milan, Milan, Italy

    P. A. Biondi

Authors
  1. E. Sacchetti
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  2. E. Smeraldi
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  3. E. Allaria
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  4. M. Cagnasso
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  5. P. A. Biondi
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Editor information

Editors and Affiliations

  1. “Mario Negri” Institute for Pharmacological Research, Milan, Italy

    Alberto Frigerio

  2. Department of Organic Chemistry, University of Western Australia, Nedlands, Western Australia, Australia

    Emilio L. Ghisalberti

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© 1977 Plenum Press, New York

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Sacchetti, E., Smeraldi, E., Allaria, E., Cagnasso, M., Biondi, P.A. (1977). MHPG, Amitriptyline and Depression: A Collaborative Study. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_16

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  • DOI: https://doi.org/10.1007/978-1-4613-4151-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4153-6

  • Online ISBN: 978-1-4613-4151-2

  • eBook Packages: Springer Book Archive

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