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Mass Fragmentography (Single and Multiple Ion Monitoring) in Drug Research

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Mass Spectrometry in Drug Metabolism

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Abstract

One of the major problems in drug research is the accurate measurement of very low levels of drugs and their metabolites in biological tissues and fluids. The technique of selected ion monitoring (SIM)″, or mass fragmentography, has been shown to be one of the most sensitive detection systems known. Simply defined, SIM is a technique in which the detection and recording systems of a mass spectrometer (MS) are dedicated to acquiring the ion current due to one or more selected ions. The sensitivity and selectivity of SIM have been amply demonstrated in the measurement of low levels of endogenous compounds, drugs and their metabolites in biological samples (1–7). Recently the technique has also been used for the detection and quantitation of pesticides and environmental pollutants (8). Since the first application of SIM for the identification of chlorpromazine and some of its metabolites in human blood (9), several reviews have appeared which discuss the principles and applications of SIM (1–7).

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Authors and Affiliations

  1. Istituto “Mario Negri”, 20157, Milan, Italy

    A. Frigerio

  2. University of W.A., Nedlands, Western Australia, Australia

    E. L. Ghisalberti

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  1. A. Frigerio
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  2. E. L. Ghisalberti
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Editor information

Editors and Affiliations

  1. “Mario Negri” Institute for Pharmacological Research, Milan, Italy

    Alberto Frigerio

  2. Department of Organic Chemistry, University of Western Australia, Nedlands, Western Australia, Australia

    Emilio L. Ghisalberti

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© 1977 Plenum Press, New York

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Frigerio, A., Ghisalberti, E.L. (1977). Mass Fragmentography (Single and Multiple Ion Monitoring) in Drug Research. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_10

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  • DOI: https://doi.org/10.1007/978-1-4613-4151-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4153-6

  • Online ISBN: 978-1-4613-4151-2

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