Abstract
Feprazone is a recently synthesised non-steroidal anti-inflammatory drug (1). It is structurally closely related to phenylbutazone, the difference lying in the side chain which is dimethylallyl in feprazone (see formula in Fig. 1) and butyl in phenylbutazone. For the purposes of the study the drug was labelled with 14C (Fig. 1) starting with [ 14C] i-diethylmalonate which was condensed with dimethylallyl chloride to give diethyldimethylallyl [2–14C] Amalonate. This was further condensed with hydrazobenzene to yield [ 14c] feprazone (2).
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References
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© 1977 Plenum Press, New York
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Donetti, A., Dring, L.G., Hirom, P.C., Williams, R.T. (1977). A Study on the Metabolism of Feprazone Utilising Mass Spectrometry. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_1
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DOI: https://doi.org/10.1007/978-1-4613-4151-2_1
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