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Neurotransmitters of the Mammalian Visual System

  • Chapter
Amino Acids as Chemical Transmitters

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 16))

Abstract

The retina is a layered structure, easy to obtain, and well described anatomically (Stell, 1972; Dowling, 1970) and is therefore a structure suitable for neurochemical investigations. Up till now a huge amount of information has been gained on the localization of putative neurotransmitters in the retina by microdissection techniques and autoradiography, for review (Graham, 1974 Bonting, 1976; Voaden, this volume).

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References

  • Balcar, V.J. & Johnston, G.A.R., 1973, High affinity uptake of transmitters: studies on the uptake of L-aspartate, GABA, L-glutamate and glycine in cat spinal cord, J. Neurochem., 20: 529–539.

    Article  PubMed  CAS  Google Scholar 

  • Bogdanski, D.F., Weissbach, H. & Udenfriend, S., 1957, The distribution of serotonin, 5-hydroxytryptophan decarboxylase and monoamine oxidase in brain, J. Neurochem., 1: 272–278.

    Article  PubMed  CAS  Google Scholar 

  • Bonting, S.L., 1976, Transmitters in the visual process (Bonting, S.L. ed. ), Pergamon Press.

    Google Scholar 

  • Bruun, A. & Ehinger, B., 1974, Uptake of certain possible neurotransmitters into retinal neurons of some mammals., Exp. Eye. Res., 19: 435–437.

    Article  PubMed  CAS  Google Scholar 

  • Casagrande, V.A., Harting, J.K., Hall, W.C. & Diamond, J.T., 1972, Superior collicuius of the tree shrew: A structural and functional subdivision into superficial and deep layers, Science, 177: 444–447.

    Article  PubMed  CAS  Google Scholar 

  • Cobbin, L.B., Leeder, S. & Pollard, J., 1965, Smooth muscle stimulants in extracts of optic nerve, optic tracts and lateral geniculate bodies of sheep, Brit. J. Pharmacol., 25: 295–306.

    PubMed  CAS  Google Scholar 

  • Crossland, J., Mitchell, J.F. & Woodruff, G.N., 1966, The presence of ergothioneine in the central nervous system and its probable identity with the cerebellar factor, J. Physiol. ( London ), 182: 427–438.

    PubMed  CAS  Google Scholar 

  • Dick, F. & Kelly, J.S., 1975, L-2,U-Diaminobutyric acid (L-DABA) as a selective marker for inhibitory nerve terminals in rat brain, Bit. J. Pharmacol., 53: 439 P.

    Google Scholar 

  • Dowling, J.E., 1970, Organization of vertebrate retinas, Invest. Ophthalmol., 9: 655–680.

    PubMed  CAS  Google Scholar 

  • Dowling, J.E. & Ehinger, B., 1975, Synaptic organization of the aminecontaining interplexiform cells of the goldfish and Cebus monkey retinas, Science, 188: 270–273.

    Article  PubMed  CAS  Google Scholar 

  • Ehinger, B. & Falck, B., 1971, Autoradiography of some suspected neurotransmitter substances: GABA, glycine, glutamic acid, histamine, dopamine and L-DOPA, Brain Res., 33: 157–172.

    Article  PubMed  CAS  Google Scholar 

  • Gosavi, V.S. & Dubey, P.N., 1972, Projection of striate cortex to the dorsal lateral geniculate body in the rat, J. Anat. ( London ), 113: 75–82.

    PubMed  CAS  Google Scholar 

  • Graham, L.T., 1972, Intraretinal distribution of GABA content and GAD activity, Brain Res., 36: 476–479.

    Article  PubMed  CAS  Google Scholar 

  • Graham, L.T., 1974, Comparative aspects of neurotransmitters in the retina. In: The Eye. Volume 6. Comparative Physiology. (Davson, H. & Graham, L.T., eds.), pp 283–342, Academic Press, N.Y., London.

    Google Scholar 

  • Graham, L.T., Lolley, R.N. & Baxter, C.F., 1968, Effect of illumination upon levels of y-aminobutyric acid and glutamic acid in frog retina in vivo, Fed. Proc., 27: 463.

    Google Scholar 

  • Guillery, R.W., 1967, Patterns of fibre degeneration in the dorsal lateral geniculate nucleus of the cat following lesions in the visual cortex, J. comp. Neurol., 130: 197–222.

    Article  PubMed  CAS  Google Scholar 

  • Hansson, H.A., 1970, Utrastructure studies on long-term effects of MSG on rat retina, Virchows Arch. B.Z. ( Cell Pathol. ), 6: 1–19.

    CAS  Google Scholar 

  • Hággendal, J. & Malmfors, T., 1965, Identification and cellular localization of the catecholamines in the retina and choroid of the rabbit, Acta Physiol, scand., 64: 58–66.

    Article  Google Scholar 

  • Iversen, L.L., Dick, F., Kelly, J.S. & Schon, F., 1975, Uptake and localization of transmitter amino acids in the nervous system. In: Metabolic compartment at i on and neurotransmission. NATO advanced study institute series. (Berl, S., Clarke, D.D. & Schneider, D., Eds.), Vol 6, pp. 65–89.

    Chapter  Google Scholar 

  • Johnson, J.L. & Aprison, M.H., 1971, The distribution of glutamate and total free amino acids in thirteen specific regions of the cat central nervous system, Brain Res., 26: 141–148.

    Article  CAS  Google Scholar 

  • Kuffler, S.W. & Nichols, J.S., 1976, The visual world cellular organization and its analysis. In: From Neuron to Brain, ( Kuffler, S.W. & Nichols, J.S., Eds.), Sunderland, Massachusetts.

    Google Scholar 

  • Langer, T.P. & Lund, R.D., 1974, The upper layers of the superior colliculus of the rat: A Golgi study, J. comp. Neur., 158: 405–436.

    Article  Google Scholar 

  • Lindberg-Bauer, A., 1975, Light evoked release of glycine from rabbit retina, Acta Ophthal., 125: 30–31.

    CAS  Google Scholar 

  • Lucas, D.R. & Newhouse, J.P., 1957, The toxic effect of sodium L- glutamate on the inner layers of the retina, Arch. Ophthal. 58: 193–201.

    Article  CAS  Google Scholar 

  • Lund, R.D., 1966, The occipitotectal pathway of the rat, J. Anat., 100.1: 51–62.

    Google Scholar 

  • Lund Karlsen, R., 1978, The toxic effect of sodium glutamate and DL-a-aminoadipic acid on rat retina: Changes in high affinity uptake of putative transmitter, J. Neurochem., Submitted for publication.

    Google Scholar 

  • Lund Karlsen, R. & Fonnum, F., 1976, The toxic effect of sodium glutamate on rat retina: Changes in putative transmitters and their corresponding enzymes, L. Neurochem., 27: 1437–1441.

    Article  Google Scholar 

  • Lund Karlsen, R. & Fonnum, F., 1978, Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colluculus in rats, Brain Res., Submitted for publication.

    Google Scholar 

  • Mandel, P., Pasantes-Morales, H. & Urban, P.F., 1976, Taurine, a putative transmitter in retina. In: Transmitters in the visual process. Mandel, P., Pasantes-Morales, H. & Urban, P.F., ed.), pp. 89–105, Pergamon Press.

    Google Scholar 

  • Marshal, J. & Voaden, M., 1974, An investigation of the cells incorporating (3H) GABA and (3H) glycine in the isolated retina of the rat, Exp. Eye. Res., 18: 367–370.

    Article  Google Scholar 

  • Miller, E., Heller, A. & Moore, R.E., 1969, Acetylcholine in rabbit visual system nuclei after enucleation and visual cortex ablation, Pharm. Exp. Ther., 165: 117–125.

    CAS  Google Scholar 

  • Montero, V.M. & Guillery, R.W., 1968, Degeneration in the dorsal lateral geniculate nucleus of the rat following interruption of the retinal or cortical connections, J. Comp. Neur., 134: 211–292.

    Article  PubMed  CAS  Google Scholar 

  • Mustari, M.J. & Lund, R.D., 1976, An aberrant crossed visual corticotectal pathway in albino rat, Brain Res., 112: 37–44.

    Article  PubMed  CAS  Google Scholar 

  • Neal, M.J., 1976, Amino acid transmitter substances in the vertebrate retina, Gen. Pharmac., 7: 321–332.

    Article  CAS  Google Scholar 

  • Nichols, C.W. & Koelle, G.B., 1968, Comparison of the localization of acetylcholinesterase and non-specific Cholinesterase activities in mammalian and avian retinas, J. Comp. Neurol., 133: 1–15.

    Article  PubMed  CAS  Google Scholar 

  • Okada, I., 1974, Distribution of γ-aminobutyric acid ( GABA) in the layers of superior colliculus of rabbit, Brain Res., 75: 363–365.

    Article  Google Scholar 

  • Olney, J.W., 1969 Glutamate - induced retinal degereration in neonatal mice. Electron microscopy of the evolving lesion, J. Neuropath, exp. Neurol., 28: 455–474.

    CAS  Google Scholar 

  • Olney, J.W., 1974, Toxic effects of glutamate and related amino acids on the developing central ñervos system. In: Heritable disorders of amino acid metabolism. ( Nyhan, W.H., Ed.), pp. 501–512, John Wiley, New York.

    Google Scholar 

  • Olney, J.W., Ho, O.L. & Rhee, V., 1971, Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system, Exp. Brain. Res., 14: 61–76.

    Article  PubMed  CAS  Google Scholar 

  • Orr, H.T., Cohen, A.I. & Carter, J.A., 1976, The levels of free taurine, glutamate, glycine and y-amino butyric acid during the postnatal development of the normal and dystrophic retina of the mouse, Exp. Eye. Res., 23: 377–384.

    Article  PubMed  CAS  Google Scholar 

  • Pasantes-Morales, H., Klethi, J., Leidig, M. & Mandel, P., 1972, Free amino acids of chicken and rat retina, Brain Res., 41: 494–497.

    Article  PubMed  CAS  Google Scholar 

  • Pasantes-Morales, H., Urban, P.F., Klethi, J. & Mandel, P., 1973, Light stimulated release of 35S-taurine from chicken retina, Brain Res., 51: 375–378.

    Article  PubMed  CAS  Google Scholar 

  • Polyak, S., 1957, The vertebrate visual system. (Klüver, H., Ed.), University of Chicago Press, Chicago.

    Google Scholar 

  • Potts, A.M., Modrell, R.W. & Kingsbury, C., 1960, Permanent fractionation of the eHectroretinogram by sodium glutamate, Am. J. Ophthal., 50: 900–907.

    PubMed  CAS  Google Scholar 

  • Repérant, J. & Angaut, P., 1977, The retinotectal projections in the pigeon. An experimental optical and electron microscope study, Neuroscience, 2: 119–140.

    Article  PubMed  Google Scholar 

  • Ribak, C.E., 1977, The immunocytochemical localization of GAD within stellate neurons of rat visual cortex, Anatomical-Record, 187: 692–693.

    Google Scholar 

  • Ross, C.D. & MacDougal, D.B., 1976, The distribution of choline acetyltransferase in vertebrate retina, J. Neurochem., 26: 521–526.

    Article  PubMed  CAS  Google Scholar 

  • Schon, F. & Kelly, J.S., 1975, Selective uptake of (3H) β-alanine by glia: association with the glial uptake system for GABA, Brain Res., 86: 243–247.

    Article  PubMed  CAS  Google Scholar 

  • Schwarcz, R. & Coyle, J.T., 1977, Kainic acid: neurotoxic effects after intraocular injection, Invest, Optithal., 16: 141–148.

    CAS  Google Scholar 

  • Simon, J.R., Atweh, S. & Kuhar, M.I., 1976, Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine, J. Neurochem., 26: 909–922.

    Article  PubMed  CAS  Google Scholar 

  • Siou, G. & Israel, M., 1969, Recherches experimentales sur la distribution de la choline-acetyltransferase dans le tectum opticum du Lapin, C.R. Soc. Biol., 3: 594–598.

    Google Scholar 

  • Snyder, S.H., Young, A.B., Bennett, J.P. & Mulder, A.H., 1973, Synaptic biochemistry of amino acids, Fed. Proc., 32: 2039–2047.

    PubMed  CAS  Google Scholar 

  • Stell, W.K., 1972, The morphological organization of the vertebrate retina. In: Handbook of sensory physiology. ( Fuortes, M.G.F., Ed.), 7: 112–213, Springer-Verlag, Berlin.

    Google Scholar 

  • Tebécis, A.K., 1973, Studies on the identity of the optic nerve transmitter, Brain Res., 63: 31–42.

    Article  PubMed  Google Scholar 

  • Valverde, F., 1968, Structural changes in the area striata of the mouse after enucleation, Exp. Brain. Res., 5: 274–292.

    CAS  Google Scholar 

  • Valverde, F. & Esteban, M.E., 1968, Peristriate cortex of mouse: location and the effects of enucleation on the number of dendritic spines, Brain Res., 9: 145–148.

    Article  PubMed  CAS  Google Scholar 

  • Voaden, M., Marshall, J. & Murani, N., 1974, The uptake of 3H-γ- aminobutyric acid and 3H glycine by the isolated retina of the frog, Brain Res., 67: 115–132.

    Article  PubMed  CAS  Google Scholar 

  • Wallaas, I. & Fonnum, F., 1978, The effect of parenteral glutamate treatment on the localization of neurotransmitters in the mediobasal hypothalamus, Brain Res., Submitted for publication.

    Google Scholar 

  • Wood, J.S., MacLaughlm, B.J. & Vaughn, I.E., 1976, Immunocyto-chemical localization of GAD in electron microscopic preparations of rodent CNS. In: GABA in nervous system function, ( Roberts, E., Chase, T.N. & Tower, D.B., Eds.), pp. 133–148, Raven Press, New York.

    Google Scholar 

  • Yates, R.A, & Roberts, P.J., 1974, Effects of enucleation and intraocular colchicine on the amino acids of frog optic tectum, J. Neurochem., 23: 891–893.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division for Toxicology, Norwegian Defence Research Establishment, P O Box 25, N-2007, Kjeller, Norway

    R. Lund Karlsen

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  1. R. Lund Karlsen
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Editors and Affiliations

  1. Norwegian Defense Research Establishment, Kjeller, Norway

    Frode Fonnum

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© 1978 Plenum Press, New York

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Karlsen, R.L. (1978). Neurotransmitters of the Mammalian Visual System. In: Fonnum, F. (eds) Amino Acids as Chemical Transmitters. NATO Advanced Study Institutes Series, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4030-0_18

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  • DOI: https://doi.org/10.1007/978-1-4613-4030-0_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4032-4

  • Online ISBN: 978-1-4613-4030-0

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