Summary
A wide spectrum of biological action is to be found among the myriad molecular structures resulting from more than a century of organosilicon chemistry. Deflatulent, hormonal, analgesic, anti-microbial, and anticonvulsant properties exhibited by silicon compounds ranging in molecular size from simple monomers to high polymers are discussed. These selected pharmacons are drawn from throughout the range of common silicon structures and are illustrative of the breadth of biological action which may be attained.
N.B. Underlined numbers in brackets refer to formulae; other numbers are references to literature cited listed at the end of the article.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Rochow, E G, The chemistry of silicon, in Comprehensive inorganic chemistry (exec. ed A F Trofman-Dickensen) pp 1323–1327. Pergamon Press, Oxford and New York, 1973.
Weeks, M E, Discovery of the elements, p 586. J Chem Education, Easton, Pa, 1956.
Friedel C & Crafts, J M, Liebigs Ann Chem 1863, 127, 31.
Kipping, F S, Proc Chem Soc 1904, 20, 15.
Dilthey, W, Chem Ber 1904, 37, 319.
Rochow, E G, US Patent 2380995, 1941.
DeNicola, R, J Urol 1950, 63, 168.
Braley, S A, Rubber Chem Technol 1971, 44, 363.
Eaborn, C, Organosilicon compounds, chapt 3. Butterworths Publications, London, 1960.
Ebsworth, E A V, Physical basis of the chemistry of the group IV elements, in Organometallic compounds of group IV elements, vol. 1, part 1 (ed A G MacDiarmid) pp 1–104. Marcel Dekker, New York, 1968.
Noll, W, Chemistry and technology of the silicones. Academic Press, New York, 1968.
Sommer, L G, Stereochemistry, mechanism and silicon. McGrawHill, New York, 1965.
Vinogradov, A P, The elementary chemical composition of marine organisms, Memoirs II, Sears Foundation for Marine Research, New Haven, Conn, 1953.
Darley, W M & Volcani, B E, Exp Cell Res 1969, 58, 334.
Werner, D, Arch Mikrobiol 1966, 55, 278.
Heinen, W, Arch Biochem Biophys 1967, 120, 101.
LeVier, R R, Bioinorganic Chem 1975, 4, 109.
Carlisle, E M, Science 1970, 167, 279.
Carlisle, E M, Science 1972, 178, 619.
Schwarz, K & Milne, D B, Nature 1972, 239, 333.
Holt, P F & Yates D M, Biochemistry 1953, 54. 300.
Holzaphfel, L, Z Ver Dtsch Ing 1943, 87, 606.
Ohlmeyer, P & Olpp, U, Hoppe-Seyl Z 1944, 281, 203.
Heinen, W, Arch Biochem Biophys 1967, 120, 86.
Schwarz, K, Proc Natl Acad Sci US 1973, 70, 1608.
Heinen, W, Arch Mikrobiol 1965, 52, 49.
Chang, E & Jain, V K J, J Med Chem 1966, 9, 433.
Fessenden, R J & Coon, M D, J Med Chem 1965, 8, 60k.
Fessenden, R J & Fessenden J S, Adv Drug Res 1967, 4, 95.
Allison, A C, Proc Roy Soc B 1968, 171, 19.
Voronkov, M G & Lukevics, E, Russ Chem Rev 1969, 38, 975.
Garson, L R & Kirchner, L K, J Pharm Sci 1971, 60, 1113.
Child, G P, Paquin, H O & Deichmann, W B, Arch Ind Hyg 1950, 1, 539.
Palazzolo, P J, McHard, J A, Hobbs, E J, Fancher, O E & Calandra, J C, Toxicol Appl Pharmacol 1972, 21, 15.
Hayden, J F & Barlow, S A, Toxicol Appl Pharmacol 1972, 21, 68.
Bennett, D R, Gorzinski, S J & LeBeau, J E, Toxicol Appl Pharmacol 1972, 21, 55.
LeVier, R R & Jankowiak, M E, Acta Pharmacol et Toxicol 1975, 36(3), 81.
LeVier, R R & Jankowiak, M E, Toxicol Appl Pharmacol 1972, 21, 80.
LeVier, R R & Boley, W F, Acta Pharmacol et Toxicol 1975, 36(3), 55.
Jankowiak, M E & LeVier, R R, Anal Biochem 1971, 44, 462.
Feldberg, W, Monoamines of the hypothalamus as mediators of temperature response, in The hypothalamus (ed Z Martini, M Motta & F Fraschini) p 213. Academic Press, New York and London, 1970.
Weetall, H H, Preparation, characterization, and applications of enzymes immobilized on inorganic supports, in Advances in experimental medicine and biology, vol 42 (ed R B Dunlop) p 191. Plenum, New York and London, 1974.
Isquith, A J, Abbott, E A & Walters, P A, Appl Microbiol 1972, 24, 859.
Mercier, J, Chemical compounds possessing anticonvulsant activity, in Int eneye pharmacol therap (ed J Mercier) sect. 19, 1973, 1, 203.
Bennett, D R, US Patent 4,006,226.
Chandler, M L, LeVier, R R & Krahnke R H, US Patent 49039,666.
Hulce, V D & Rech R H, Pharmacologist 1974, 16, 228.
Hulce, V D, Soderberg, L, Secton, M & Rech, R, Fed Proc 1975, 34, 628.
Chandler, M L & LeVier, R R, Pharmacologist 1977. In press.
Kipping, F S, J Chem Soc 1912, 101, 2125.
Toman, J E P, Swinyard, E A & Goodman, L S, J Neurophysiol 1946, 9, 231.
Orloff, M J, Williams, H L & Pfeiffer, C C, Proc Soc Exp Biol Med 1949, 70, 254.
Lieu, E J, Tong, G L, Chou, J T & Lieu, L L, J Pharm Sci 1973, 63, 246.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
LeVier, R.R., Chandler, M.L., Wendel, S.R. (1978). The Pharmacology of Silanes and Siloxanes. In: Bendz, G., Lindqvist, I., Runnström-Reio, V. (eds) Biochemistry of Silicon and Related Problems. Nobel Foundation Symposia, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4018-8_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4018-8_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4020-1
Online ISBN: 978-1-4613-4018-8
eBook Packages: Springer Book Archive