Skip to main content

The Pharmacology of Silanes and Siloxanes

  • Chapter
Biochemistry of Silicon and Related Problems

Part of the book series: Nobel Foundation Symposia ((NOFS,volume 40))

Summary

A wide spectrum of biological action is to be found among the myriad molecular structures resulting from more than a century of organosilicon chemistry. Deflatulent, hormonal, analgesic, anti-microbial, and anticonvulsant properties exhibited by silicon compounds ranging in molecular size from simple monomers to high polymers are discussed. These selected pharmacons are drawn from throughout the range of common silicon structures and are illustrative of the breadth of biological action which may be attained.

N.B. Underlined numbers in brackets refer to formulae; other numbers are references to literature cited listed at the end of the article.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rochow, E G, The chemistry of silicon, in Comprehensive inorganic chemistry (exec. ed A F Trofman-Dickensen) pp 1323–1327. Pergamon Press, Oxford and New York, 1973.

    Google Scholar 

  2. Weeks, M E, Discovery of the elements, p 586. J Chem Education, Easton, Pa, 1956.

    Google Scholar 

  3. Friedel C & Crafts, J M, Liebigs Ann Chem 1863, 127, 31.

    Google Scholar 

  4. Kipping, F S, Proc Chem Soc 1904, 20, 15.

    Google Scholar 

  5. Dilthey, W, Chem Ber 1904, 37, 319.

    Article  Google Scholar 

  6. Rochow, E G, US Patent 2380995, 1941.

    Google Scholar 

  7. DeNicola, R, J Urol 1950, 63, 168.

    CAS  Google Scholar 

  8. Braley, S A, Rubber Chem Technol 1971, 44, 363.

    Article  CAS  Google Scholar 

  9. Eaborn, C, Organosilicon compounds, chapt 3. Butterworths Publications, London, 1960.

    Google Scholar 

  10. Ebsworth, E A V, Physical basis of the chemistry of the group IV elements, in Organometallic compounds of group IV elements, vol. 1, part 1 (ed A G MacDiarmid) pp 1–104. Marcel Dekker, New York, 1968.

    Google Scholar 

  11. Noll, W, Chemistry and technology of the silicones. Academic Press, New York, 1968.

    Google Scholar 

  12. Sommer, L G, Stereochemistry, mechanism and silicon. McGrawHill, New York, 1965.

    Google Scholar 

  13. Vinogradov, A P, The elementary chemical composition of marine organisms, Memoirs II, Sears Foundation for Marine Research, New Haven, Conn, 1953.

    Google Scholar 

  14. Darley, W M & Volcani, B E, Exp Cell Res 1969, 58, 334.

    Article  PubMed  CAS  Google Scholar 

  15. Werner, D, Arch Mikrobiol 1966, 55, 278.

    Article  CAS  Google Scholar 

  16. Heinen, W, Arch Biochem Biophys 1967, 120, 101.

    Article  PubMed  CAS  Google Scholar 

  17. LeVier, R R, Bioinorganic Chem 1975, 4, 109.

    Article  CAS  Google Scholar 

  18. Carlisle, E M, Science 1970, 167, 279.

    Article  PubMed  CAS  Google Scholar 

  19. Carlisle, E M, Science 1972, 178, 619.

    Article  PubMed  CAS  Google Scholar 

  20. Schwarz, K & Milne, D B, Nature 1972, 239, 333.

    Article  PubMed  CAS  Google Scholar 

  21. Holt, P F & Yates D M, Biochemistry 1953, 54. 300.

    CAS  Google Scholar 

  22. Holzaphfel, L, Z Ver Dtsch Ing 1943, 87, 606.

    Google Scholar 

  23. Ohlmeyer, P & Olpp, U, Hoppe-Seyl Z 1944, 281, 203.

    Article  CAS  Google Scholar 

  24. Heinen, W, Arch Biochem Biophys 1967, 120, 86.

    Article  PubMed  CAS  Google Scholar 

  25. Schwarz, K, Proc Natl Acad Sci US 1973, 70, 1608.

    Article  CAS  Google Scholar 

  26. Heinen, W, Arch Mikrobiol 1965, 52, 49.

    Article  PubMed  CAS  Google Scholar 

  27. Chang, E & Jain, V K J, J Med Chem 1966, 9, 433.

    Article  PubMed  CAS  Google Scholar 

  28. Fessenden, R J & Coon, M D, J Med Chem 1965, 8, 60k.

    Article  Google Scholar 

  29. Fessenden, R J & Fessenden J S, Adv Drug Res 1967, 4, 95.

    PubMed  CAS  Google Scholar 

  30. Allison, A C, Proc Roy Soc B 1968, 171, 19.

    Article  CAS  Google Scholar 

  31. Voronkov, M G & Lukevics, E, Russ Chem Rev 1969, 38, 975.

    Article  Google Scholar 

  32. Garson, L R & Kirchner, L K, J Pharm Sci 1971, 60, 1113.

    Article  PubMed  CAS  Google Scholar 

  33. Child, G P, Paquin, H O & Deichmann, W B, Arch Ind Hyg 1950, 1, 539.

    Google Scholar 

  34. Palazzolo, P J, McHard, J A, Hobbs, E J, Fancher, O E & Calandra, J C, Toxicol Appl Pharmacol 1972, 21, 15.

    Article  CAS  Google Scholar 

  35. Hayden, J F & Barlow, S A, Toxicol Appl Pharmacol 1972, 21, 68.

    Article  PubMed  CAS  Google Scholar 

  36. Bennett, D R, Gorzinski, S J & LeBeau, J E, Toxicol Appl Pharmacol 1972, 21, 55.

    Article  PubMed  CAS  Google Scholar 

  37. LeVier, R R & Jankowiak, M E, Acta Pharmacol et Toxicol 1975, 36(3), 81.

    CAS  Google Scholar 

  38. LeVier, R R & Jankowiak, M E, Toxicol Appl Pharmacol 1972, 21, 80.

    Article  CAS  Google Scholar 

  39. LeVier, R R & Boley, W F, Acta Pharmacol et Toxicol 1975, 36(3), 55.

    CAS  Google Scholar 

  40. Jankowiak, M E & LeVier, R R, Anal Biochem 1971, 44, 462.

    Article  PubMed  CAS  Google Scholar 

  41. Feldberg, W, Monoamines of the hypothalamus as mediators of temperature response, in The hypothalamus (ed Z Martini, M Motta & F Fraschini) p 213. Academic Press, New York and London, 1970.

    Google Scholar 

  42. Weetall, H H, Preparation, characterization, and applications of enzymes immobilized on inorganic supports, in Advances in experimental medicine and biology, vol 42 (ed R B Dunlop) p 191. Plenum, New York and London, 1974.

    Google Scholar 

  43. Isquith, A J, Abbott, E A & Walters, P A, Appl Microbiol 1972, 24, 859.

    PubMed  CAS  Google Scholar 

  44. Mercier, J, Chemical compounds possessing anticonvulsant activity, in Int eneye pharmacol therap (ed J Mercier) sect. 19, 1973, 1, 203.

    Google Scholar 

  45. Bennett, D R, US Patent 4,006,226.

    Google Scholar 

  46. Chandler, M L, LeVier, R R & Krahnke R H, US Patent 49039,666.

    Google Scholar 

  47. Hulce, V D & Rech R H, Pharmacologist 1974, 16, 228.

    Google Scholar 

  48. Hulce, V D, Soderberg, L, Secton, M & Rech, R, Fed Proc 1975, 34, 628.

    Google Scholar 

  49. Chandler, M L & LeVier, R R, Pharmacologist 1977. In press.

    Google Scholar 

  50. Kipping, F S, J Chem Soc 1912, 101, 2125.

    Article  Google Scholar 

  51. Toman, J E P, Swinyard, E A & Goodman, L S, J Neurophysiol 1946, 9, 231.

    PubMed  CAS  Google Scholar 

  52. Orloff, M J, Williams, H L & Pfeiffer, C C, Proc Soc Exp Biol Med 1949, 70, 254.

    PubMed  CAS  Google Scholar 

  53. Lieu, E J, Tong, G L, Chou, J T & Lieu, L L, J Pharm Sci 1973, 63, 246.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Press, New York

About this chapter

Cite this chapter

LeVier, R.R., Chandler, M.L., Wendel, S.R. (1978). The Pharmacology of Silanes and Siloxanes. In: Bendz, G., Lindqvist, I., Runnström-Reio, V. (eds) Biochemistry of Silicon and Related Problems. Nobel Foundation Symposia, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4018-8_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4018-8_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4020-1

  • Online ISBN: 978-1-4613-4018-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics