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Aging and Involution of the Immunological Apparatus

  • Chapter
The Immunopathology of Lymphoreticular Neoplasms

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 4))

Abstract

Thymic involution and involution of the thymus-dependent system of cells responsible for cell-mediated immunity (CMI) occur in man as they do in all animals that possess a thymus. Specific thymic alterations related to aging were described and extensively discussed by Hammar (1926) and have been reviewed by many others (Good and Gabrielson, 1964). It has been known for many years that beginning at the time of sexual maturation, an apparent programmed involution begins in the central lymphoid organs. This is succeeded by a period of gradual involution of the peripheral lymphoid apparatus and declining vigor of immunological functions (Walford, 1969; Roberts-Thomson et al., 1974; Yunis et al., 1968, 1971a,b; Stutman et al., 1968; Good and Yunis, 1974). In both man and mouse, the rate of immunological decline is highly variable. In aging research, fundamental questions to be answered focus on the determinants of variability in life span, i.e., longevity. The variability and thus the rate of immunological involution clearly implicate genetic determinants, as described later, but immunological involution, as with other aging processes, proceeds according to a schedule that fits a broad framework characteristic of the species.

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Authors and Affiliations

  1. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    E. J. Yunis

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    G. Fernandes & Robert A. Good

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  1. E. J. Yunis
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  2. G. Fernandes
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  3. Robert A. Good
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Editors and Affiliations

  1. Veterans Administration Hospital, Houston, Texas, USA

    J. J. Twomey M.B. (N.U.I.), F.A.C.P.

  2. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Robert A. Good Ph.D., M.D.

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Yunis, E.J., Fernandes, G., Good, R.A. (1978). Aging and Involution of the Immunological Apparatus. In: Twomey, J.J., Good, R.A. (eds) The Immunopathology of Lymphoreticular Neoplasms. Comprehensive Immunology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4015-7_3

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