Abstract
The common denominator in ail plasma–cell dyscrasias (PCDs) is the inordinate expansion of differentiated B–cell clones (plasma cells) capable of synthesis and secretion of immunoglobulin (Ig) or its subunits. The structurally homogeneous secreted proteins can be demonstrated in the serum and urine of the overwhelming majority of patients. In only rare instances can no secreted product be demonstrated, and infrequently, two or more clones can be shown to occur simultaneously (see Section 4.1.10f).
ArticleNote
Abbreviations used in this chapter: (CLL) Chronic lymphocytic leukemia; (DNP) dinitrophenyl; (FCR) fractional catabolic rate; (H chain) heavy chain; (HCD) heavy–chain disease; (Ig) immunoglobulin; (L chain) light chain; (MM) multiple myeloma; (PCD) plasma–cell dyscrasia; (PCDUS) plasma–cell dyscrasia(s) of unknown significance; (PHA) phytohemagglutinin; (PV) plasma volume; (RES) reticuloendothelial system; (V region) variable region; (WM) Waldenstrom’s macroglobulinemia; (BMG) benign monoclonal gammopathy; (LM) lichen myxedematosus.
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Farhangi, M., Osserman, E.F. (1978). Biology, Clinical Patterns, and Treatment of Multiple Myeloma and Related Plasma–Cell Dyscrasias. In: Twomey, J.J., Good, R.A. (eds) The Immunopathology of Lymphoreticular Neoplasms. Comprehensive Immunology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4015-7_22
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