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Ventilatory Control Characteristics of Conditions Resulting In Isocapnic Hyperpnea

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The Regulation of Respiration During Sleep and Anesthesia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 99))

Abstract

The steady state of dynamic muscular exercise of moderate intensity is an isocapnic conditionl1, 2, 3, seemingly mediated, wholly or in large part, by a signal proportional to the altered rate of C02 flux to the lung4. Evidence exists which demonstrates that the sensory mechanism is likely to be downstream of the pulmonary capillary beds5, 6, However, the nature of the C02-linked stimulus is not clear at present nor is the receptor mechanism(s).

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References

  1. Whipp, B.J. and Wasserman, K.: Alveolar-arterial gas tension differences during graded exercise. J. Appl. Physiol. 27: 361–365, 1969.

    PubMed  Google Scholar 

  2. Wasserman, K., Van Kessel, A.L. and Burton, G.G.: Interaction of physiological mechanisms during exercise. J. Appl. Physiol. 22:71–85, 1967.

    PubMed  Google Scholar 

  3. Hansen, J.E., Stelter, G.P. and Vogel, J.A.: Arterial pryuvate, lactate, pH and PC0 2 during work at sea level and high altitude J. Appl. Physiol. 23523–530, 19

    PubMed  Google Scholar 

  4. Casaburi, R., Whipp, B.J., Wasserman, K., Beaver, W.L. and Koyal, S.N.: Ventilatory and gas exchange dynamics in response to sinusoidal work. J. Appl. Physiol. 42:300–311, 1977.

    PubMed  Google Scholar 

  5. Cropp, G.J.A. and Comroe, J.H., Jr.: Role of mixed venous C02 in respiratory control. J. Appl. Physiol. 16:1029–1033, 1961.

    PubMed  Google Scholar 

  6. Sylvester, J.T., Whipp, B.J. and Wasserman, K.: Ventilatory control during brief infusions of C02-laden blood in the awake dog. J. Appl. Physiol. 35:178–186, 1973.

    PubMed  Google Scholar 

  7. Wasserman, K., Whipp, B.J. and Castagna, J.: Cardiodynamic hyperpnea: hyperpnea secondary to cardiac output increase. J. Appl. Physiol. 36:457–464, 1974.

    PubMed  Google Scholar 

  8. Juratsch, C.E., Whipp, B.J., Laks, M., Garner, D., Beazell, J. and Jengo, J.: Ventilatory responses to non-occlusive distension of the main pulmonary artery in the conscious dog. Physiologist 16:355, 1973.

    Google Scholar 

  9. Yamamoto, W.S. and Edwards, M.W.: Homeostasis of carbon dioxide during intravenous infusion of carbon dioxide. J. Appl. Physiol. 15:807–818, 1960.

    PubMed  Google Scholar 

  10. Wasserman, K., Whipp, B.J., Casaburi, R., Huntsman, D.J., Castagna, J. and Lugliani, R.: Regulation of arterial PC0 2 during intravenous C02 loading. J. Appl. Physiol. 38: 651-656, 1975.

    Google Scholar 

  11. Stremel, R.W., Huntsman, D.J., Casaburi R., Whipp, B.J. and Wasserman, K.: Control of ventilation during intravenous C02 loading in the awake dog. J. Appl. Physiol. (in press).

    Google Scholar 

  12. Saltzman, H.A. and Sieker, H.O.: Intestinal response to changing gaseous environment: normobaric and hyperbaric observations. Ann. N.Y. Acad. Sci. 150:31–39, 1968.

    Article  PubMed  Google Scholar 

  13. Ponte, J. and Purves, M.J.: Ventilation and the C02 content of mixed venous blood. J. Physiol. (London) 263:148P, 1976.

    Google Scholar 

  14. Linton, R.A.F., Miller, R. and Cameron, I.R.: Ventilatory response to C02 inhalation and intravenous infusion of hypercapnic blood. Respir. Physiol. 26:383–394, 1976.

    Article  PubMed  Google Scholar 

  15. Lewis,.: Awake baboon’s ventilatory response to venous and inhaled C02 loading. J. Appl. Physiol. 39:417–422, 1975.

    Google Scholar 

  16. Brown, H.V., Wasserman, K. and Whipp, B.J.: Effect of betaadrenergic blockade during exercise on ventilation and gas exchange. J. Appl. Physiol. 41:886–892, 1976.

    PubMed  Google Scholar 

  17. Lefran~ois, R., Gautier, N., Pasquis, P. and Vargas, E.: Factors controlling respiration during muscular exercise at altitude. Fed. Proc. 28:1296–1300, 1969.

    PubMed  Google Scholar 

  18. Wasserman, K.: Testing regulation of ventilation with exercise. Chest 70:173S–178S, 1976.

    Google Scholar 

  19. Dejours, P.: Control of respiration by arterial chemoreceptors. Ann. N.Y. Acad. Sci. 109:682–695, 1963.

    Google Scholar 

  20. Cunningham, D.J.C.: Integrative aspects of the regulation of breathing: a personal view. In: International Review of Science, Physiology. Series I. Respiratory Physiology, Vol. II.Butterworths,London, 19

    Google Scholar 

  21. Asmussen, E. and Nielsen, M.: Studies on the regulation of respiration in heavy work. Acta Physiol. Scand. 12:171–188, 1946.

    Article  Google Scholar 

  22. Casaburi, R., Stremel, R.W., Whipp, B.J. and Wasserman, K.: Coupling of ventilation to gas exchange at the onset of exercise. (Manuscript in preparation.)

    Google Scholar 

  23. Lugliani, R., Whipp, B.J., Seard, C. and Wasserman, K.: Effects of bilateral carotid body resection on ventilatory control at rest and during exercise in man. J. Engl. J. Med. 285:1105–1111, 1971.

    Article  Google Scholar 

  24. Wasserman, K., Whipp, B.J., Koyal, S.N. and Cleary, M.G.: Effect of carotid body resection on ventilatory and acid-base control during exercise. J. Appl. Physiol. 38:651–656, 1975.

    PubMed  Google Scholar 

  25. Cunningham, D.J.C.: J.S. Haldane’s realization of the significance for the arterial 02 content of the ventilationperfusion ratio. J. Physiol. (London) 263:80P, Y.

    Google Scholar 

  26. West, J.B.: Causes of carbon dioxide retention in lung disease. N. Engl. J. Med. 284:1232–1236, 1971.

    Article  PubMed  Google Scholar 

  27. Morgan, D.P. and Grodins, F.S.: Regulation of breathing during electrically induced exercise in the intact anesthetized dog. Am. J. Physiol. 162:54–63, 1950.

    PubMed  Google Scholar 

  28. Kao, F.F., Schlag, B.B. and McC. Brooks, C.: Regulation of respiration during induced muscular work in decerebrate dogs. J. Appl. Physiol. 7:379–386, 1955.

    PubMed  Google Scholar 

  29. Agostoni, E. and D’Angelo, E.: The effect of limb movement on the regulation of depth and rate of breathing. Respir. Physiol. 27:33–52, 1976.

    Article  PubMed  Google Scholar 

  30. Weissman, M., Wasserman, K. and Whipp, B.J.: Dynamics of ventilatory control, arterial PC0 and gas exchange during exercise in anesthetized cats. Physiologist (in press).

    Google Scholar 

  31. Rodgers, S.N.: Ventilatory response to ventral root stimulation in the decerebrate cat. Respir. Physiol. 5:165–174, 1968.

    Article  PubMed  Google Scholar 

  32. Krogh, A. and Lindhard, J.: A comparison between voluntary and electrically induced muscular work in man. J. Physiol. (London) 51:182–201, 1917.

    PubMed  Google Scholar 

  33. Grodins, F.S. and James, G.: Mathematical models of respiratory regulation. Ann. N.Y. Acad. Sci. 109:852–868, 1963.

    Article  PubMed  Google Scholar 

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© 1978 Plenum Press, New York

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Whipp, B.J., Wasserman, K., Casaburi, R., Juratsch, C.E., Weissman, M.L., Stremel, R.W. (1978). Ventilatory Control Characteristics of Conditions Resulting In Isocapnic Hyperpnea. In: Fitzgerald, R.S., Gautier, H., Lahiri, S. (eds) The Regulation of Respiration During Sleep and Anesthesia. Advances in Experimental Medicine and Biology, vol 99. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4009-6_38

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  • DOI: https://doi.org/10.1007/978-1-4613-4009-6_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4011-9

  • Online ISBN: 978-1-4613-4009-6

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