Abstract
Afferent vagal endings with non-myelinated axons are widely distributed in the lungs, where they are considerably more umerous than the endings of myelinated fibers. Until recently this group of C-fibers has been thought of as a single, functionally homogeneous afferent input. Action potential studies in both dogsl and cats2 indicated that chemicals injected into the bloodstream gained access to the endings through the pulmonary circulation, and Paintal2 obtained good evidence that they were situated near the pulmonary capillaires; he, therefore, named them “juxtapulmonary capillary receptors (type J receptors)”. When stimulated by chemicals, these endings give rise to the pulmonary chemoreflex triad of bradycardia, systemic vasodilatation and apnea.
Supported by U.S. Public Health Service Program Project Grant HL-06285 from the National Heart, Lung and Blood Institute.
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© 1978 Plenum Press, New York
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Coleridge, H.M., Coleridge, J.C.G., Baker, D.G., Ginzel, K.H., Morrison, M.A. (1978). Comparison of the Effects of Histamine and Prostaglandin on Afferent C-Fiber Endings and Irritant Receptors in the Intrapulmonary Airways. In: Fitzgerald, R.S., Gautier, H., Lahiri, S. (eds) The Regulation of Respiration During Sleep and Anesthesia. Advances in Experimental Medicine and Biology, vol 99. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4009-6_32
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DOI: https://doi.org/10.1007/978-1-4613-4009-6_32
Publisher Name: Springer, Boston, MA
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