Abstract
About 50 years ago Henriques1 calculated the rate of dehydration of bicarbonate to CO2 in the lung capillaries. He showed that the uncatalyzed reaction is too slow to allow sufficient transfer of CO2 during the short time the blood spends in the capillaries. This stimulated the search for an enzyme which catalyzes the reaction, and in 1933 Meldrum and Roughton2 and Stadie and O’Brien3 reported the presence of such an enzyme, carbonic anhydrase, in red cells. In 1935 Roughton4 suggested that because carbonic anhydrase is absent in plasma, the rate of pH changes in plasma must be slow, and that pH changes in circulating blood would be less than the difference observed between arterial and venous blood samples. Surprisingly, however, actual measurements of the rate of pH changes in blood were not made until recently5, 6, 7.
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Hill, E.P., Power, G.G., Gilbert, R.D. (1978). Slow pH Changes in Blood Plasma Following C02 Exchange. In: Fitzgerald, R.S., Gautier, H., Lahiri, S. (eds) The Regulation of Respiration During Sleep and Anesthesia. Advances in Experimental Medicine and Biology, vol 99. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4009-6_26
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DOI: https://doi.org/10.1007/978-1-4613-4009-6_26
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