Abstract
Anesthesia induces changes in the mechanical characteristics of the respiratory system and in the ventilatory control setting. Since ventilation depends not only on neural output and muscle contraction but also on the impedance of the system, one could assume that mechanical and ventilatory modifications could interact. It is well known that both passive1, 2 and effective elastance3 are increased under anesthesia. Yet there is still some controversy about the time course of these changes. On the other hand, sighs or augmented big breaths have been reported to be scarce, and this low frequency of periodic inflation of the lungs is assumed to be responsible at least for part of the increased elastance of the lungs4. In the present study, we have investigated the time course of the changes in the mechanical properties of the respiratory system and the nature and frequency of sighs in the awake and anesthetized state.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Howell, J.B.L. and Peckett, B.W.: Studies of the elastic properties of the thorax of supine anesthetized paralyzed human subjects. J. Physiol. (London) 1–19, 1957.
Westbrook, P.R., Stubbs, S.E., Sessler, A.D., Rehder, K.,and Hyatt, R.E.: Effects of anesthesia and muscle paralysis on on respiratory mechanics in normal man. J. Appl. Physiol. 34:81–86, 1973.
Margaria, C.E., Iscoe, S., Pengelly, L.D., Couture, J., Don, H. and Milic-Emili, J.: Immediate ventilatory response to elastic loads and positive pressure in man. Respir. Physiol. 18:347–369, 1973.
Egbert, L.D., Laver, M.D. and Bendixen, H.H.: Intermittent deep breaths and compliance during anesthesia in man. Anesthesiology 24:57–60, 1963.
Derenne, J.Ph., Couture, J., Iscoe, S., Whitelaw, W.A. and Milic-Emili, J.: Occlusion pressures in men rebreathing CO2under methoxyflurane anesthesia. J. App1. Physiol. 40:805–814, 1976.
Read, D.J.C.: A clinical method for assessing the ventilatory response to carbon dioxide. Austral. Ann. Med. 16:20–32, 1967.
Heaf, P.J.D. and Prime, F.L.: The compliance of the thorax in normal human subjects. C1in. Sci. 15:319–327, 1956.
Goldman, M.S.: The effects of fentanyl and thiopental on breathing in man. In: this volume, p. 117.
Derenne, J.Ph., Roussos, C., Bussi, S., Gaudy, J.H. and Gautier, H.: Immediate effects of thiopental on the chestwall dimension in man. Bull. Eur. Physiopath. Respir. 13:87P, 1977.
Harvey, S.C.: Hypnotics and sedative the barbiturates. In: The Pharmacological Basis of Therapeutics, 5th Edition, edited by L.S. Goodman and A. Gilman. MacMillan, New York, 1975, pp. 102–123.
Derenne, J.Ph. and Murciano, D.: Chemical dependence of sighs in anesthetized cats. Proc. Int. Un. Physiol. Sci. 13:179, 1977.
Whitelaw, W.A., Derenne, J.Ph. and Milic-Emili, J.: Occlusion pressure as a measure of respiratory center output in conscious man. Respir. Physiol. 23:181–199, 1975.
Milic-Emili, J. and Pengelly, L.D.: Ventilatory effects of mechanical loading. In: The Respiratory Muscles, edited by E.J.M. Campbell, E. Agostoni andJ. Newsom-Davis. Lloyd Luke, London, 1970, pp. 271–290.
Whitelaw, W.A., Derenne, J.Ph., Couture, J. and Milic-Emili, J.: Adaptation of anesthetized men to breathing through an inspiratory resistor. J. Appl. Physiol. 41:285–291, 1976.
Guz, A., Noble, M.I.M., Eisele, J.H. and Trenchard, D.: The role of vagal inflation reflexes in man and other mammals. In: Breathing-Hearing-Breuer Centenary Symposium, edited by R. Porter. Churchill, London, 1970, pp. 17–40.
De1hez, L.: Contribution electromyographique a l’etude de la mecanique et du controle nerveux des mouvements respiratoires de l’homme. Vaillant-Carmanne, Liege, 1974.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Derenne, J.P., Couture, J., Whitelaw, W.A., Milic-Emili, J. (1978). Interaction Between the Mechanical Properties of the Respiratory System and Drive in the Control of Breathing of Anesthetized Man. In: Fitzgerald, R.S., Gautier, H., Lahiri, S. (eds) The Regulation of Respiration During Sleep and Anesthesia. Advances in Experimental Medicine and Biology, vol 99. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4009-6_12
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4009-6_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4011-9
Online ISBN: 978-1-4613-4009-6
eBook Packages: Springer Book Archive