Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations-Applications to Alprenolol in Rats and Dogs

  • T. Walle
  • K. Walle

Abstract

As the number of adrenergic beta-blocking drugs with potential usefulness in man rapidly increases, the need to expand our knowledge of these agents also increases. An improved insight into the biological fate of these drugs is necessary to be able to understand the actions they produce, both beneficial and maybe also toxic. It is known, for example, that several beta-blocking drugs produce pharmacologically active metabolites. A metabolites of propranolol with intact beta-blocking side-chain, 4-hydroxy- propranolol, is equipotent to propranolol as a beta-blocker in animals (1) and would appear to contribute to the effects of propranolol in man (2, 3). Other metabolites of propranolol, such as the glycollic and N-desalkylated metabolites, have also been shown to possess pharmacologic activity (4–6), metabolites which would be expected to be common to beta-blocking drugs in general.

Keywords

Vortex Benzene Anhydride Propranolol Naphthalene 

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • T. Walle
    • 1
  • K. Walle
    • 1
  1. 1.Department of PharmacologyMedical University of South CarolinaCharlestonUSA

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