Abstract
The derivatization of prostaglandins A1 and A2 with BSTFA/ piperidine (1/1) at 60°C for 1 hour gives a new type of derivative (piperidyl-PGA (TMS)3) whose mass spectral pattern is characterized by a very abundant M-173 fragment. The proposed mechanism of nucleo- philic addition of piperidine on the C-11 of PGAs has now been shown to apply as well to the reaction of PGA1 with 1/1 mixtures of BSTFA and other nitrogen containing heterocyclics such as pyrrolidine, propylenimine, morpholine or hexamethylenimine which give the corresponding pyrrolidyl-, propyleniminyl-, morpholyl-, or hexamethyleniminyl- PGA (TMS)3 derivatives, respectively, all of them also giving a base peak at M-173.
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© 1978 Plenum Press, New York
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Rosselló, J., Suñol, C., Gelpí, E. (1978). A New Derivatization Approach for the Determination of Prostaglandin A1 by Mass Fragmentography. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3991-5_18
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DOI: https://doi.org/10.1007/978-1-4613-3991-5_18
Publisher Name: Springer, Boston, MA
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