Abstract
Analysis of chemically labile compounds is a difficult and frequently encountered problem in organic and biomedical chemistry. High pressure liquid chromatography (hplc) is an effective technique for these analyses because only mild sample handling conditions are used. Hplc applications are limited, however, by the lack of a sensitive universal detection system. Direct probe chemical ionization (ci) techniques also employ mild sample handling conditions and provide sensitive qualitatively significant mass spectral data (1–5).
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References
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© 1978 Plenum Press, New York
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Weinkam, R.J., Stearns, J., Lin, H.S., Levin, V.A. (1978). Chemical Ionization Techniques for the Analysis of Labile Compounds: 1,3-bis-(2-chloroethyl)-1-nitrosourea Plasma Clearance and Degradation. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3991-5_14
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DOI: https://doi.org/10.1007/978-1-4613-3991-5_14
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